A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication (Q24307609)

8

object named as

Tamotsu Yoshimori

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author name string

Toru Okamoto

1

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Hiroko Omori

2

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Yuuki Kaname

3

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Takayuki Abe

4

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Yorihiro Nishimura

5

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Tetsuro Suzuki

6

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Tatsuo Miyamura

7

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Kohji Moriishi

Cellular cofactors affecting hepatitis C virus infection and replication

9

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language of work or name

English

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publication date

April 2008

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published in

Journal of Virology

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volume

82

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issue

7

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page(s)

3480-9

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Robust hepatitis C virus infection in vitro

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Amphipathic Helix-Dependent Localization of NS5A Mediates Hepatitis C Virus RNA Replication

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

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1 reference

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1 reference

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Complete replication of hepatitis C virus in cell culture

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1 reference

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1 reference

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

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1 reference

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1 reference

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1 reference

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The lipid droplet is an important organelle for hepatitis C virus production

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Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction

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1 reference

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FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues

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1 reference

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Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

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1 reference

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268450

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1 reference

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1 reference

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1 reference

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