Small-molecule inhibition of APT1 affects Ras localization and signaling (Q24307840)

palmitoyl-(protein) hydrolase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Herbert Waldmann

17

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Frank J Dekker

Frank J Dekker

1

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Daniel Rauh

Daniel Rauh

13

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Luc Brunsveld

Luc Brunsveld

15

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Rengarajan Balamurugan

Rengarajan Balamurugan

6

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author name string

Oliver Rocks

2

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Nachiket Vartak

3

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Sascha Menninger

4

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Christian Hedberg

5

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Stefan Wetzel

7

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Steffen Renner

8

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Marc Gerauer

9

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Beate Schölermann

10

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Marion Rusch

11

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John W Kramer

12

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Geoffrey W Coates

14

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Philippe I H Bastiaens

A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS)

16

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language of work or name

English

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publication date

June 2010

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published in

Nature Chemical Biology

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volume

6

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issue

6

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page(s)

449-56

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cites work

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2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro

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The on-off story of protein palmitoylation

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Depalmitoylation of endothelial nitric-oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca(2+)-calmodulin

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Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways

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Labeling and quantifying sites of protein palmitoylation

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Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening

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Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.

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Ras signalling on the endoplasmic reticulum and the Golgi

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Development and Biological Evaluation of Acyl Protein Thioesterase 1 (APT1) Inhibitors

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Asymmetric aldol additions: use of titanium tetrachloride and (-)-sparteine for the soft enolization of N-acyl oxazolidinones, oxazolidinethiones, and thiazolidinethiones

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An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

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Use of analogs and inhibitors to study the functional significance of protein palmitoylation

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2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes

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Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion

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Bioorganic synthesis of lipid-modified proteins for the study of signal transduction.

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Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids.

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Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation

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The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins

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Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.362

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO.362

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

4647510

1012204629

0 references

4647510

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference