Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4 (Q24309550)

response to mechanical stimulus

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Gabriel L Galea

1

0 references

Lee B Meakin

object named as

Lee B Meakin

3

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Toshihiro Sugiyama

object named as

Toshihiro Sugiyama

5

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author name string

Andrew Sunters

2

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Gul Zaman

4

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Lance E Lanyon

6

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Joanna S Price

Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression

7

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language of work or name

English

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publication date

4 August 2011

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published in

FEBS Letters

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volume

585

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issue

15

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page(s)

2450-4

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cites work

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Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

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Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

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Cbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)

19 March 2017

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EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures

19 March 2017

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Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway

19 March 2017

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Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading

27 September 2017

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Denosumab and bisphosphonates: different mechanisms of action and effects.

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Modulation of sclerostin expression by mechanical loading and bone morphogenetic proteins in osteogenic cells

27 September 2017

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The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity

27 September 2017

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Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor.

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The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading

27 September 2017

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The role of tissue-nonspecific alkaline phosphatase in the phosphate-induced activation of alkaline phosphatase and mineralization in SaOS-2 human osteoblast-like cells

27 September 2017

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Effect of deletion of the prostaglandin EP2 receptor on the anabolic response to prostaglandin E2 and a selective EP2 receptor agonist

27 September 2017

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Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha

27 September 2017

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Early responses of osteoblast-like cells to different mechanical signals through various signaling pathways

27 September 2017

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SOST is a target gene for PTH in bone

27 September 2017

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Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin

27 September 2017

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Effects of mechanical strain on proliferation and differentiation of bone marrow stromal cell line ST2.

27 September 2017

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Discovery of a potent and selective agonist of the prostaglandin EP4 receptor

27 September 2017

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Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways

27 September 2017

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Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation

27 September 2017

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Mechanical strain and estrogen activate estrogen receptor alpha in bone cells

27 September 2017

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Indomethacin modulation of load-related stimulation of new bone formation in vivo

27 September 2017

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Recombinant human parathyroid hormone

27 September 2017

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Kappa Delta Award paper. Osteoregulatory nature of mechanical stimuli: function as a determinant for adaptive remodeling in bone.

30 May 2018

1 reference

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Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5

30 May 2018

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Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice

19 June 2018

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Crossref

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.06.019

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.06.019

Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo

21 January 2018

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12 December 2020

Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation

1 reference

12 December 2020

Effects of a prostaglandin EP4 agonist, ONO-4819, and risedronate on trabecular microstructure and bone strength in mature ovariectomized rats

1 reference

12 December 2020

Modulation of human estrogen receptor α F promoter by a protein kinase C/c-Src-dependent mechanism in osteoblast-like cells

1 reference

12 December 2020

Bone formation and tooth movement are synergistically enhanced by administration of EP4 agonist

1 reference

12 December 2020

Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss

1 reference

12 December 2020

Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading

1 reference

12 December 2020

Effect of a selective agonist for prostaglandin E receptor subtype EP4 (ONO-4819) on the cortical bone response to mechanical loading

1 reference

12 December 2020