The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells (Q24310314)

positive regulation of tyrosine phosphorylation of STAT protein

GOA release 2020-03-11

1 reference

Signal transducer and activator of transcription 4

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Koh Yamamoto

1

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Fumi Shibata

2

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Nobuyuki Miyasaka

3

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Osamu Miura

Biochemical and Biophysical Research Communications

4

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language of work or name

English

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publication date

11 October 2002

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published in

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volume

297

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issue

5

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page(s)

1245-52

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cites work

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Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

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Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

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Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

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A central role of perforin in cytolysis?

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Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers

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Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity

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Components of a Stat recognition code: evidence for two layers of molecular selectivity

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Differential regulation of interleukin-12- and interleukin-15-induced natural killer cell activation by interleukin-4.

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Binding sequence of STAT4: STAT4 complex recognizes the IFN-gamma activation site (GAS)-like sequence (T/A)TTCC(C/G)GGAA(T/A).

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STATs: signal transducers and activators of transcription

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Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain

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The significance of tetramerization in promoter recruitment by Stat5.

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Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin 2 (IL-2) stimulation of IL-2 receptor alpha gene transcription

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Structure of the amino-terminal protein interaction domain of STAT-4

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The biology of Stat4 and Stat6

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Structure and function of human perforin

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Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation

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Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis

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Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

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Characterization of cytokine differential induction of STAT complexes in primary human T and NK cells

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-291X(02)02378-1

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12372421

1 reference

Consolidated OpenCitations Corpus – April 2017