Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus (Q24310340)

GOA release 2020-03-11

apoptotic process

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GOA release 2020-03-11

toxicity

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author name string

A Lorenzo

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B Razzaboni

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G C Weir

3

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B A Yankner

On the Relation of Chronic Interstitial Pancreatitis to the Islands of Langerhans and to Diabetes Melutus

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language of work or name

English

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publication date

21 April 1994

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published in

Nature

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volume

368

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issue

6473

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page(s)

756-60

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cites work

1 reference

7 January 2021

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

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Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

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Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle

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Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro.

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Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

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Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-beta neurotoxicity

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pH-dependent structural transitions of Alzheimer amyloid peptides

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Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

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Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species

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Rat amylin: cloning and tissue-specific expression in pancreatic islets

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Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone

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Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity

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Cell death: the significance of apoptosis

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The relation of islet amyloid to the clinical type of diabetes

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Neurotoxicity of a prion protein fragment.

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Identification of prion amyloid filaments in scrapie-infected brain.

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Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35.

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Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

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Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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Replication of adult pancreatic-beta cells cultured on bovine corneal endothelial cell extracellular matrix

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New fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopy

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