Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product (Q24310468)

DNA-binding transcription factor activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

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8

S J Korsmeyer

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author name string

P H Domer

1

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S S Fakharzadeh

2

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C S Chen

3

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J Jockel

4

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L Johansen

5

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G A Silverman

6

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J H Kersey

Proceedings of the National Academy of Sciences of the United States of America

7

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language of work or name

English

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publication date

15 August 1993

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published in

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volume

90

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page(s)

7884-8

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issue

16

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The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

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V(D)J recombination gets a break

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The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase

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Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics.

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Relationship of the human protooncogene CBL2 on 11q23 to the t(4;11), t(11;22), and t(11;14) breakpoints

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Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations

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A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

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Identification of the constant chromosome regions involved in human hematologic malignant disease

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12 December 2020

Eukaryotic transcription factors

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12 December 2020

Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases

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12 December 2020

An altered 11-kilobase transcript in leukemic cell lines with the t(4;11)(q21;q23) chromosome translocation

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12 December 2020

The der(11) chromosome contains the critical breakpoint junction in the 4;11, 9;11, and 11;19 translocations in acute leukemia

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12 December 2020

Breakpoints at 11q23 in infant leukemias with the t(11;19)(q23;p13) are clustered

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12 December 2020

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

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12 December 2020