Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine (Q24311432)

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English	Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine	scientific article

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17 October 2019

Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine (English)

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17 October 2019

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Phospholipase A2 group IVA

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GOA release 2020-03-11

phospholipase A2 activity

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GOA release 2020-03-11

Edward A. Dennis

9

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17 October 2019

author name string

R T Pickard

1

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17 October 2019

X G Chiou

2

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17 October 2019

B A Strifler

3

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17 October 2019

M R DeFelippis

4

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17 October 2019

P A Hyslop

5

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17 October 2019

A L Tebbe

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17 October 2019

Y K Yee

7

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17 October 2019

L J Reynolds

8

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17 October 2019

R M Kramer

10

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17 October 2019

J D Sharp

11

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17 October 2019

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publication date

1 August 1996

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17 October 2019

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7

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Journal of Biological Chemistry

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17 October 2019

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17 October 2019

32

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17 October 2019

19225-19231

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17 October 2019

Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7.

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21 January 2018

Metal ion and salt effects on the phospholipase A2, lysophospholipase, and transacylase activities of human cytosolic phospholipase A2.

1 reference

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21 January 2018

A continuous fluorescence-based assay for the human high-molecular-weight cytosolic phospholipase A2.

1 reference

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21 January 2018

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP

1 reference

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21 January 2018

Evolutionary relationships and implications for the regulation of phospholipase A2 from snake venom to human secreted forms.

1 reference

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21 January 2018

Interfacial catalysis: the mechanism of phospholipase A2

1 reference

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21 January 2018

Methylation of histidine-48 in pancreatic phospholipase A2. Role of histidine and calcium ion in the catalytic mechanism

1 reference

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21 January 2018

Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19225

21 January 2018

Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad

1 reference

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21 January 2018

Structure of human pancreatic lipase

1 reference

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21 January 2018

Enzymology. More of the catalytic triad.

1 reference

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21 January 2018

A serine protease triad forms the catalytic centre of a triacylglycerol lipase

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1 reference

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Characterization by electrospray mass spectrometry of human Ca(2+)-sensitive cytosolic phospholipase A2 produced in baculovirus-infected insect cells

1 reference

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21 January 2018

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

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Homology modelling and protein engineering strategy of subtilases, the family of subtilisin-like serine proteinases

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Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis

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Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP

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21 January 2018

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1 reference

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21 January 2018

The catalytic cysteine and histidine in the plant acyl-acyl carrier protein thioesterases

1 reference

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21 January 2018

Functional topology of a surface loop shielding the catalytic center in lipoprotein lipase

1 reference

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21 January 2018

Dissecting the catalytic triad of a serine protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19225

21 January 2018

Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: absence of the conserved structural water

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19225

21 January 2018

Function of the fully conserved residues Asp99, Tyr52 and Tyr73 in phospholipase A2.

1 reference

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21 January 2018

Role of cysteine residues in the activity of rat glutathione transferase P (7-7): elucidation by oligonucleotide site-directed mutagenesis

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Role of cysteine residues in ribonuclease H from Escherichia coli. Site-directed mutagenesis and chemical modification

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21 January 2018

Inactivation of a cytosolic phospholipase A2 by thiol-modifying reagents: cysteine residues as potential targets of phospholipase A2.

1 reference

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21 January 2018

Arginine 53 is involved in head-group specificity of the active site of porcine pancreatic phospholipase A2.

1 reference

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21 January 2018

Low-barrier hydrogen bonds and enzymic catalysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.32.19225

21 January 2018

A low-barrier hydrogen bond in the catalytic triad of serine proteases

1 reference

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21 January 2018

Understanding the rates of certain enzyme-catalyzed reactions: proton abstraction from carbon acids, acyl-transfer reactions, and displacement reactions of phosphodiesters

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21 January 2018

Identification of the potential active site of the signal peptidase SipS of Bacillus subtilis. Structural and functional similarities with LexA-like proteases

1 reference

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21 January 2018

Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution

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The role of electrostatic interactions in the mechanism of peptide bond hydrolysis by a Ser-Lys catalytic dyad

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7 January 2021

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