Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium (Q24311749)

positive regulation of intracellular signal transduction

GOA release 2020-03-11

1 reference

Molecular and Cellular Biology

GOA release 2020-03-11

3

S Ananth Karumanchi

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author name string

Hai Tao Yuan

series ordinal

1

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Eliyahu V Khankin

series ordinal

2

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Samir M Parikh

series ordinal

4

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language of work or name

English

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publication date

April 2009

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published in

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volume

29

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page(s)

2011-22

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issue

8

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cites work

Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans

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A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function

19 March 2017

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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

19 March 2017

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Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

19 March 2017

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Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo

19 March 2017

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Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

19 March 2017

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Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration

19 March 2017

1 reference

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Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

19 March 2017

1 reference

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Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

19 March 2017

1 reference

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Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Vascular-specific growth factors and blood vessel formation

19 March 2017

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Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass.

7 April 2017

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Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy

27 September 2017

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Intra and extravascular transmembrane signalling of angiopoietin-1-Tie2 receptor in health and disease

27 September 2017

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Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Hypoxic regulation of angiopoietin-2 expression in endothelial cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Overexpression of VEGF and angiopoietin 2: a key to high vascularity of hepatocellular carcinoma?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

In vivo receptor binding of the opiate partial agonist, buprenorphine, correlated with its agonistic and antagonistic actions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Signaling and regulation of endothelial cell survival by angiopoietin-2.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Leptin induces angiopoietin-2 expression in adipose tissues

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

COMP-Ang1, angiopoietin-1 variant protects radiation-induced bone marrow damage in C57BL/6 mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1-dependent autocrine production of interleukin-8.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Angiopoietin correlates with glomerular capillary loss in anti-glomerular basement membrane glomerulonephritis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2663314

Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells

29 November 2018

1 reference

12 December 2020

Tumor necrosis factor-alpha upregulates angiopoietin-2 in human umbilical vein endothelial cells

1 reference

12 December 2020

Complementary and coordinated roles of the VEGFs and angiopoietins during normal and pathologic vascular formation

1 reference

12 December 2020

HSP90 and Akt modulate Ang-1-induced angiogenesis via NO in coronary artery endothelium

1 reference

12 December 2020

Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells

1 reference

12 December 2020

Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation

1 reference

12 December 2020