Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms (Q24311866)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

3

Heath Ecroyd

0 references

Chris Dobson

4

Christopher M Dobson

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Amy R. Wyatt

Amy R Wyatt

1

0 references

Mark R. Wilson

Mark R Wilson

5

0 references

Justin Yerbury

7

Justin J Yerbury

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Janet R Kumita

6

Janet R Kumita

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author name string

Patrick Constantinescu

Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies using a baboon model

2

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language of work or name

English

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publication date

1 March 2013

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published in

FEBS Letters

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volume

587

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issue

5

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page(s)

398-403

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cites work

1 reference

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Protein misfolding, functional amyloid, and human disease

19 March 2017

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19 March 2017

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Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity.

7 April 2017

1 reference

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Effect of retinal laser photocoagulation on the activity of metalloproteinases and the alpha(2)-macroglobulin proteolytic state in the vitreous of eyes with proliferative diabetic retinopathy

27 September 2017

1 reference

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Alpha 2-macroglobulin-mediated degradation of amyloid beta 1--42: a mechanism to enhance amyloid beta catabolism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581772

Alpha2-macroglobulin: an evolutionarily conserved arm of the innate immune system

27 September 2017

1 reference

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Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation

27 September 2017

1 reference

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27 September 2017

Alpha 2-macroglobulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581772

Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin.

27 September 2017

1 reference

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Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation

27 September 2017

1 reference

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Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics

27 September 2017

1 reference

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A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis

27 September 2017

1 reference

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A protective role of the low density lipoprotein receptor-related protein against amyloid beta-protein toxicity

30 May 2018

1 reference

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Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3581772

alpha2-Macroglobulin as a beta-amyloid peptide-binding plasma protein.

30 May 2018

1 reference

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Conformation and protease binding activity of binary and ternary human alpha 2-macroglobulin-protease complexes

30 May 2018

1 reference

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Localization of epsilon-lysyl-gamma-glutamyl cross-links in five human alpha 2-macroglobulin-proteinase complexes. Nature of the high molecular weight cross-linked products

30 May 2018

1 reference

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Measurement of the 'fast' or complexed form of alpha 2 macroglobulin in biological fluids using a sandwich enzyme immunoassay.

30 May 2018

1 reference

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Preparation of amyloid beta-protein for structural and functional studies

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.01.020

Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity

21 January 2018

1 reference

12 December 2020

alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species

1 reference

12 December 2020

Role of alpha2-macroglobulin in regulating amyloid beta-protein neurotoxicity: protective or detrimental factor?

1 reference

12 December 2020

Tissue-type plasminogen activator is a multiligand cross-beta structure receptor

1 reference

12 December 2020

Circulating level of alpha2-macroglobulin-beta2-microglobulin complex in hemodialysis patients

1 reference

12 December 2020

Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis

1 reference

12 December 2020

Predominant Role of Neutrophils in the Inactivation of α2-Macroglobulin in Arthritic Joints

1 reference

12 December 2020

Elevated conversion of alpha-2-macroglobulin to the complexed form in gingival crevicular fluid from adult periodontitis patients

1 reference

12 December 2020

The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species

1 reference

12 December 2020