TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta (Q24311973)

Tribbles pseudokinase 2

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negative regulation of fat cell differentiation

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Tribbles pseudokinase 2

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Tribbles pseudokinase 3

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1 reference

Takahiro Naiki

1

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Eiko Saijou

2

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Yuichiro Miyaoka

3

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Keisuke Sekine

4

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Atsushi Miyajima

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

17 August 2007

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published in

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volume

282

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page(s)

24075-82

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issue

33

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cites work

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Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

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Differential roles of insulin receptor substrates in brown adipocyte differentiation

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A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila

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Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis

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Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation

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The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation

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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

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Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

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Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells

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Oncostatin M inhibits adipogenesis through the RAS/ERK and STAT5 signaling pathways

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C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage

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Transcriptional repression of pref-1 by glucocorticoids promotes 3T3-L1 adipocyte differentiation

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The forkhead transcription factor Foxo1 regulates adipocyte differentiation

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SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia

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TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism

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Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.

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Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia

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7 January 2021

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA

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7 January 2021

Generation of truncated C/EBPbeta isoforms by in vitro proteolysis

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7 January 2021

Understanding adipocyte differentiation

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7 January 2021