Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression (Q24312056)

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1 January 2020

title

Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression (English)

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1 January 2020

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5

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1 January 2020

author name string

Haidong Gao

1

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1 January 2020

Zhigang Yu

2

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1 January 2020

Dongsong Bi

3

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1 January 2020

Liyu Jiang

4

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1 January 2020

Jingzhong Sun

6

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1 January 2020

Rong Ma

7

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1 January 2020

language of work or name

English

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publication date

19 June 2007

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Molecular and Cellular Biochemistry

1 January 2020

published in

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1 January 2020

volume

305

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1 January 2020

issue

1-2

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1 January 2020

page(s)

35-44

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https://scigraph.springernature.com/pub.10.1007/s11010-007-9525-3

1 January 2020

exact match

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cites work

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

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Modulation of Akt kinase activity by binding to Hsp90

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Akt regulates growth by directly phosphorylating Tsc2

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Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

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Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

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PI3K: downstream AKTion blocks apoptosis

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The protooncogene TCL1 is an Akt kinase coactivator

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Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

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Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

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PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

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Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

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Genomic structure and expression of the mouse ESET gene encoding an ERG-associated histone methyltransferase with a SET domain

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AKT plays a central role in tumorigenesis

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

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Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

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Cellular survival: a play in three Akts

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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SET domain protein lysine methyltransferases: Structure, specificity and catalysis.

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Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest

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Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

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Regulation of cell death protease caspase-9 by phosphorylation

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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12 December 2020

PKB binding proteins. Getting in on the Akt.

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12 December 2020

The akt kinase: molecular determinants of oncogenicity

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12 December 2020

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

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12 December 2020

Role for the adaptor protein Grb10 in the activation of Akt

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12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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12 December 2020

PKB/AKT: functional insights from genetic models

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12 December 2020

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

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12 December 2020

Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor

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12 December 2020

Akt/PKB regulates actin organization and cell motility via Girdin/APE

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12 December 2020

The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells

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12 December 2020

Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

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12 December 2020

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

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12 December 2020

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

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12 December 2020

The diverse functions of histone lysine methylation

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12 December 2020

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

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12 December 2020

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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12 December 2020

Role of translocation in the activation and function of protein kinase B

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12 December 2020

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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12 December 2020

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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12 December 2020

Ten years of protein kinase B signalling: a hard Akt to follow

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12 December 2020

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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12 December 2020