Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells (Q24312901)

regulation of calcium ion-dependent exocytosis

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RAB27A, member RAS oncogene family

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Unc-13 homolog D

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Double C2, alpha

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author name string

Hironori Higashio

1

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Noriyuki Nishimura

2

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Hiroyoshi Ishizaki

3

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Jun Miyoshi

4

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Satoshi Orita

5

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Ayuko Sakane

6

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Takuya Sasaki

The C2 domain calcium-binding motif: structural and functional diversity

7

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language of work or name

English

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publication date

1 April 2008

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published in

Journal of Immunology

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volume

180

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issue

7

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page(s)

4774-84

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cites work

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Doc2: a novel brain protein having two repeated C2-like domains

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Molecular cloning of an isoform of Doc2 having two C2-like domains

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Doc2gamma, a third isoform of double C2 protein, lacking calcium-dependent phospholipid binding activity.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Evolution of the Rab family of small GTP-binding proteins

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Involvement of Rab27 in antigen-induced histamine release from rat basophilic leukemia 2H3 cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Calcium-dependent regulation of exocytosis

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Calcium concentration threshold and translocation kinetics of EGFP-DOC2B expressed in cultured Aplysia neurons

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

The ins and outs of IgE-dependent mast-cell exocytosis

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Cytotoxic T lymphocyte exocytosis: bring on the SNAREs!

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Function of the t-SNARE SNAP-23 and secretory carrier membrane proteins (SCAMPs) in exocytosis in mast cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

SNAREs and associated regulators in the control of exocytosis in the RBL-2H3 mast cell line

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Microtubule-dependent transport of secretory vesicles in RBL-2H3 cells

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Rab proteins as membrane organizers

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Integrated signalling pathways for mast-cell activation

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

SNAREs--engines for membrane fusion

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

1 reference

7 January 2021

Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Is double C2 protein (DOC2) expressed in bovine adrenal medulla? A commercial anti-DOC2 monoclonal antibody recognizes a major bovine mitochondrial antigen

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Regulation by bivalent cations of phospholipid binding to the C2A domain of synaptotagmin III.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Rab27b regulates number and secretion of platelet dense granules

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

1 reference

7 January 2021

Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Doc2 enhances Ca2+-dependent exocytosis from PC12 cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

C2-domains, structure and function of a universal Ca2+-binding domain

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

The last exon of SNAP-23 regulates granule exocytosis from mast cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Ca(2+)-induced recruitment of the secretory vesicle protein DOC2B to the target membrane.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Calmodulin is involved in the Ca2+-dependent activation of ceramide kinase as a calcium sensor

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Rab27a is required for regulated secretion in cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

A general role for Rab27a in secretory cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Munc13-4 is an effector of rab27a and controls secretion of lysosomes in hematopoietic cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Regulating secretory lysosomes

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Dynamics of intracellular granules with CD63-GFP in rat basophilic leukemia cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta).

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Enzymes of the mast cell granule

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Linking albinism and immunity: the secrets of secretory lysosomes

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Small GTP-binding proteins

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Synaptotagmin III is a critical factor for the formation of the perinuclear endocytic recycling compartment and determination of secretory granules size

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

The roles of Rab27 and its effectors in the regulated secretory pathways

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Expression and function of synaptotagmin VII in CTLs

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021

Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.180.7.4774

7 January 2021