A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis (Q24313488)

Syntaxin 1A

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regulation of insulin secretion

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Vesicle-associated membrane protein 2

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Cell division cycle 42

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Journal of Biological Chemistry

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Angela K Nevins

1

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Debbie C Thurmond

series ordinal

2

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language of work or name

English

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publication date

21 January 2005

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published in

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volume

280

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page(s)

1944-52

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issue

3

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cites work

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A redistribution of actin and myosin IIA accompanies Ca(2+)-dependent insulin secretion

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Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets

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Motile Events in Pancreatic Endocrine Cells*

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Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex

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Glucose regulates the cortical actin network through modulation of Cdc42 cycling to stimulate insulin secretion

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Regulation of guanine-nucleotide binding proteins in islet subcellular fractions by phospholipase-derived lipid mediators of insulin secretion

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Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion

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A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release.

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Regulation of insulin-stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes

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Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue

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Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell

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Characterization of prenylcysteine methyltransferase in insulin-secreting cells

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Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing

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SNAP receptors implicated in vesicle targeting and fusion

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Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes

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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

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Synaptophysin I controls the targeting of VAMP2/synaptobrevin II to synaptic vesicles.

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21 January 2018

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Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells

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Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cells

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Intracellular ATP directly blocks K+ channels in pancreatic B-cells

21 January 2018

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Pancreatic islet glucose metabolism and regulation of insulin secretion

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7 January 2021

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly

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Voltage-gated Ca2+ current in pancreatic B-cells

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Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes

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Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

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7 January 2021