The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins (Q24313641)

NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase

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Structural maintenance of chromosomes 5

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cellular senescence

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Nature Structural & Molecular Biology

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Patrick Ryan Potts

1

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Hongtao Yu

series ordinal

2

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language of work or name

English

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publication date

July 2007

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published in

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volume

14

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issue

7

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page(s)

581-90

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cites work

Extension of life-span by introduction of telomerase into normal human cells

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Human telomerase and its regulation

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The first molecular details of ALT in human tumor cells

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Nuclear structure in normal and Bloom syndrome cells

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Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

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Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex.

20 April 2017

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SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.

20 April 2017

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Human MMS21/NSE2 is a SUMO ligase required for DNA repair

20 April 2017

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A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization

20 April 2017

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Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks

20 April 2017

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Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination.

20 April 2017

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Shelterin: the protein complex that shapes and safeguards human telomeres

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Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors

20 April 2017

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NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

20 April 2017

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PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1

20 April 2017

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Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks

20 April 2017

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Homologous recombination generates T-loop-sized deletions at human telomeres

20 April 2017

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Telomeres shorten during ageing of human fibroblasts

20 April 2017

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Switching and signaling at the telomere

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Regulation of telomerase by telomeric proteins

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A survey of telomerase activity in human cancer

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An alternative pathway for yeast telomere maintenance rescues est1- senescence

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SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting

20 April 2017

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Alternative lengthening of telomeres in mammalian cells

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Telomere maintenance by recombination in human cells.

21 January 2018

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Alternative lengthening of telomeres is characterized by high rates of telomeric exchange.

21 January 2018

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Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

21 January 2018

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Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells

21 January 2018

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The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

21 January 2018

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Localization of hRad9, hHus1, hRad1, and hRad17 and caffeine-sensitive DNA replication at the alternative lengthening of telomeres-associated promyelocytic leukemia body

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SMC proteins and chromosome mechanics: from bacteria to humans

21 January 2018

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Sister chromatid cohesion: the beginning of a long and beautiful relationship

21 January 2018

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The making of the mitotic chromosome: modern insights into classical questions

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The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair.

21 January 2018

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Rad18 is required for DNA repair and checkpoint responses in fission yeast

21 January 2018

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SUMO, ubiquitin's mysterious cousin

21 January 2018

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Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

21 January 2018

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Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

21 January 2018

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Role of SUMO in the dynamics of telomere maintenance in fission yeast

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Review: properties and assembly mechanisms of ND10, PML bodies, or PODs

21 January 2018

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Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies

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SUMO: of branched proteins and nuclear bodies

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Smc5/6 is required for repair at collapsed replication forks

21 January 2018

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Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.

21 January 2018

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Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

21 January 2018

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Telomere elongation in immortal human cells without detectable telomerase activity

31 March 2020

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The role of SMC proteins in the responses to DNA damage

31 March 2020

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A new SUMO ligase in the DNA damage response

31 March 2020

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Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways

31 March 2020

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SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae

31 March 2020

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Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB1259

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

996750

1051355165

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996750

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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