Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function (Q24314515)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Chung-ke Chang

1

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Ming-hui Chiang

2

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Elsie Khai-Woon Toh

3

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Chi-Fon Chang

4

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Tai-huang Huang

Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function

5

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language of work or name

English

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publication date

18 March 2013

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published in

FEBS Letters

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volume

587

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page(s)

575-82

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issue

6

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cites work

1 reference

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Nuclear factor TDP-43 binds to the polymorphic TG repeats in CFTR intron 8 and causes skipping of exon 9: a functional link with disease penetrance

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TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing

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Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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TAR DNA-binding protein 43 in neurodegenerative disease

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Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

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Structural insights into TDP-43 in nucleic-acid binding and domain interactions

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Induction of amyloid fibrils by the C-terminal fragments of TDP-43 in amyotrophic lateral sclerosis

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TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing

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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

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Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

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Multiple nucleic acid binding sites and intrinsic disorder of severe acute respiratory syndrome coronavirus nucleocapsid protein: implications for ribonucleocapsid protein packaging.

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Thermofluor-based high-throughput stability optimization of proteins for structural studies

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Strong hydrophobic nature of cysteine residues in proteins

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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

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High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis.

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The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity

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inferred from DOI database lookup

7 January 2021

based on heuristic

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS).

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inferred from DOI database lookup

7 January 2021

based on heuristic

Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs

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