Structural basis for androgen specificity and oestrogen synthesis in human aromatase (Q24314572)

GOA release 2020-03-11

aromatase activity

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Crystal structure of human cytochrome P450 2D6

GOA release 2020-03-11

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1

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author name string

Jennifer Griswold

series ordinal

2

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Mary Erman

series ordinal

3

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Walter Pangborn

series ordinal

4

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language of work or name

English

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publication date

8 January 2009

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published in

Nature

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volume

457

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page(s)

219-23

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issue

7226

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820300

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

19 March 2017

1 reference

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Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants

19 March 2017

1 reference

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19 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

19 March 2017

1 reference

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The CCP4 suite: programs for protein crystallography

19 March 2017

1 reference

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UCSF Chimera--a visualization system for exploratory research and analysis

19 March 2017

1 reference

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Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

19 March 2017

1 reference

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Mechanistic studies on C-19 demethylation in oestrogen biosynthesis

19 March 2017

1 reference

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Aromatase inhibitors in adjuvant therapy for hormone receptor positive breast cancer: a systematic review

19 March 2017

1 reference

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The ins and outs of cytochrome P450s.

27 September 2017

1 reference

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Structure–function studies of aromatase and its inhibitors: a progress report

27 September 2017

1 reference

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Peripheral heme substituents control the hydrogen-atom abstraction chemistry in cytochromes P450.

27 September 2017

1 reference

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Evaluation of the mechanism of aromatase cytochrome P450. A site-directed mutagenesis study

27 September 2017

1 reference

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Mechanistic studies on aromatase and related C-C bond cleaving P-450 enzymes

27 September 2017

1 reference

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Structure-function studies of human aromatase

27 September 2017

1 reference

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Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820300

Structure-function studies of human aromatase by site-directed mutagenesis: kinetic properties of mutants Pro-308----Phe, Tyr-361----Phe, Tyr-361----Leu, and Phe-406----Arg

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820300

Expression of a recombinant derivative of human aromatase P450 in insect cells utilizing the baculovirus vector system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820300

Core glycosylation of cytochrome P-450(arom). Evidence for localization of N terminus of microsomal cytochrome P-450 in the lumen.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820300

A three-dimensional model of aromatase cytochrome P450.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820300

Molecular basis for the interaction of four different classes of substrates and inhibitors with human aromatase.

30 May 2018

1 reference

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Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism

29 November 2018

1 reference

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Crystal structures of the ferrous dioxygen complex of wild-type cytochrome P450eryF and its mutants, A245S and A245T: investigation of the proton transfer system in P450eryF.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820300

The final catalytic step of cytochrome p450 aromatase: a density functional theory study.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820300

Suppression of human cytochrome P450 aromatase activity by monoclonal and recombinant antibody fragments and identification of a stable antigenic complex.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820300

A detailed molecular model for human aromatase

29 November 2018

1 reference

12 December 2020

Purification and characterization of human placental aromatase cytochrome P-450

1 reference

12 December 2020

Purification of human placental aromatase cytochrome P-450 with monoclonal antibody and its characterization

1 reference

12 December 2020

Kinetic properties of aromatase mutants Pro308Phe, Asp309Asn, and Asp309Ala and their interactions with aromatase inhibitors

1 reference

12 December 2020

Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione

1 reference

12 December 2020

Mechanism of human placental aromatase: a new active site model

1 reference

12 December 2020

Purification to homogeneity of aromatase from human placenta

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE07614

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Dimensions Publication ID

1677550

1039837934

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1677550

1 reference

1 reference

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