Progress in the understanding of the protein C anticoagulant pathway (Q24314863)

Protein C, inactivator of coagulation factors Va and VIIIa

Europe PubMed Central

title

Progress in the understanding of the protein C anticoagulant pathway (English)

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main subject

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negative regulation of blood coagulation

GOA release 2020-03-11

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International Journal of Hematology

GOA release 2020-03-11

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Björn Dahlbäck

1

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language of work or name

English

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publication date

February 2004

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published in

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volume

79

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issue

2

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page(s)

109-16

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cites work

The regulation of clotting factors

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Crossref

https://api.crossref.org/works/10.1532%2FIJH97.03149

Cleavage of factor V at Arg 506 by activated protein C and the expression of anticoagulant activity of factor V

21 January 2018

1 reference

12 December 2020

Structural investigation of the A domains of human blood coagulation factor V by molecular modeling

1 reference

12 December 2020

Science review: role of coagulation protease cascades in sepsis

1 reference

12 December 2020

Identification of functionally important amino acid residues within the C2-domain of human factor V using alanine-scanning mutagenesis

1 reference

12 December 2020

Cleavage of factor VIII heavy chain is required for the functional interaction of a2 subunit with factor IXA

1 reference

12 December 2020

Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII

1 reference

12 December 2020

Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

1 reference

12 December 2020

Activated protein C resistance and thrombosis: molecular mechanisms of hypercoagulable state due to FVR506Q mutation

1 reference

12 December 2020

Probing the activation of protein C by the thrombin-thrombomodulin complex using structural analysis, site-directed mutagenesis, and computer modeling

1 reference

12 December 2020

Localization of a hydrophobic binding site for anticoagulant protein S on the beta -chain of complement regulator C4b-binding protein.

1 reference

12 December 2020

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon

1 reference

12 December 2020

Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs

1 reference

12 December 2020

Three-dimensional model of coagulation factor Va bound to activated protein C

1 reference

12 December 2020

Factor V and protein S as synergistic cofactors to activated protein C in degradation of factor VIIIa.

1 reference

12 December 2020

The endothelial cell protein C receptor

1 reference

12 December 2020

A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin.

1 reference

12 December 2020

Factor V: Dr. Jeckyll and Mr. Hyde.

1 reference

12 December 2020

Endothelial cell protein C receptor plays an important role in protein C activation in vivo

1 reference

12 December 2020

Protein S and thrombotic disease

1 reference

12 December 2020

Mutations in a potential phospholipid binding loop in the C2 domain of factor V affecting the assembly of the prothrombinase complex

1 reference

12 December 2020

The Protein C Pathway

1 reference

12 December 2020

The C-terminal region of the factor V B-domain is crucial for the anticoagulant activity of factor V.

1 reference

12 December 2020

Mutation of protease domain residues Lys37-39 in human protein C inhibits activation by the thrombomodulin-thrombin complex without affecting activation by free thrombin

1 reference

12 December 2020

The complement regulator C4b-binding protein analyzed by molecular modeling, bioinformatics and computer-aided experimental design

1 reference

12 December 2020

Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester

1 reference

12 December 2020

The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis

1 reference

12 December 2020

A model describing the inactivation of factor Va by APC: bond cleavage, fragment dissociation, and product inhibition

1 reference

12 December 2020

Role of free protein S and C4b binding protein in regulating the coagulant response to Escherichia coli

1 reference

12 December 2020

The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways

1 reference

12 December 2020

Role of thrombin signalling in platelets in haemostasis and thrombosis

1 reference

12 December 2020

Factor V and thrombotic disease: description of a janus-faced protein

1 reference

12 December 2020

Novel vitamin K-dependent pathways regulating cell survival

1 reference

12 December 2020

1 reference

12 December 2020

Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide

1 reference

12 December 2020

The binding of protein S and the protein S-C4BP complex to neutrophils is apoptosis dependent

1 reference

12 December 2020

Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C

1 reference

12 December 2020

Synergistic cofactor function of factor V and protein S to activated protein C in the inactivation of the factor VIIIa - factor IXa complex -- species specific interactions of components of the protein C anticoagulant system

1 reference

12 December 2020

Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b

1 reference

12 December 2020

Risk factors for venous thrombosis: prevalence, risk, and interaction.

1 reference

12 December 2020

Factor V enhances the cofactor function of protein S in the APC-mediated inactivation of factor VIII: influence of the factor VR506Q mutation

1 reference

12 December 2020

Expression and function of the endothelial protein C receptor in human neutrophils

1 reference

12 December 2020

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

1 reference

12 December 2020

Efficacy and safety of recombinant human activated protein C for severe sepsis

1 reference

12 December 2020

Crystal structures of the membrane-binding C2 domain of human coagulation factor V

1 reference

12 December 2020

Stabilization of monocyte chemoattractant protein-1-mRNA by activated protein C.

1 reference

12 December 2020

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

1 reference

12 December 2020

Protein C pathway in sepsis

1 reference

12 December 2020

The amino-terminal module of the C4b-binding protein beta-chain contains the protein S-binding site

1 reference

12 December 2020

Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappaB.

1 reference

12 December 2020

Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.

1 reference

12 December 2020

C4b-binding protein exacerbates the host response to Escherichia coli

1 reference

12 December 2020

C4b-binding protein (C4BP) beta-chain Short Consensus Repeat-2 specifically contributes to the interaction of C4BP with protein S

1 reference

12 December 2020

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12 December 2020

Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.

1 reference

12 December 2020

Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va.

1 reference

12 December 2020

Structure of the C2 domain of human factor VIII at 1.5 A resolution

1 reference

12 December 2020

Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex

1 reference

12 December 2020

Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity

1 reference

12 December 2020

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

1 reference

12 December 2020

Protein S confers neuronal protection during ischemic/hypoxic injury in mice.

1 reference

12 December 2020

Role of CCP2 of the C4b-binding protein β-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies

1 reference

12 December 2020

1 reference

12 December 2020

3-Dimensional structure of membrane-bound coagulation factor VIII: modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography

1 reference

12 December 2020

Recombinant human activated protein C: a system modulator of vascular function for treatment of severe sepsis

1 reference

12 December 2020

Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells

1 reference

12 December 2020

The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites

1 reference

12 December 2020

The factor VIII Structure and Mutation Resource Site: HAMSTeRS version 4

1 reference

12 December 2020

The crystal structure of the endothelial protein C receptor and a bound phospholipid

1 reference

12 December 2020

The discovery of activated protein C resistance

1 reference

12 December 2020

Regulation of factor VIIIa in the intrinsic factor Xase

1 reference

12 December 2020

The fourth epidermal growth factor-like domain of thrombomodulin interacts with the basic exosite of protein C.

1 reference

12 December 2020

Homology models of the C domains of blood coagulation factors V and VIII: a proposed membrane binding mode for FV and FVIII C2 domains

1 reference

12 December 2020

Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C

1 reference

12 December 2020

Factor V Q506 mutation (activated protein C resistance) associated with reduced intrapartum blood loss--a possible evolutionary selection mechanism

1 reference

12 December 2020