Fhit is a physiological target of the protein kinase Src (Q24315088)

GOA release 2020-03-11

8

Carlo M Croce

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author name string

Yuri Pekarsky

1

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Preston N Garrison

2

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Alexey Palamarchuk

3

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Nicola Zanesi

4

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Rami I Aqeilan

5

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Kay Huebner

6

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Larry D Barnes

Proceedings of the National Academy of Sciences of the United States of America

7

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language of work or name

English

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publication date

16 March 2004

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published in

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volume

101

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issue

11

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page(s)

3775-9

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cites work

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

The tumor spectrum in FHIT-deficient mice

19 March 2017

1 reference

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Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

Muir-Torre-like syndrome in Fhit-deficient mice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

Proposal for a common nomenclature for sequence ions in mass spectra of peptides

19 March 2017

2 references

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19 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic

6 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells

27 September 2017

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Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

Regulation of both apoptosis and cell survival by the v-Src oncoprotein.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

Replacement of Fhit in cancer cells suppresses tumorigenicity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

Recognition and specificity in protein tyrosine kinase-mediated signalling

27 September 2017

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Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein

27 September 2017

1 reference

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Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer.

30 May 2018

1 reference

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Loss of FHIT expression in gastric carcinoma.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

Structure and expression of the human FHIT gene in normal and tumor cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=374320

The tumor suppressor protein Fhit. A novel interaction with tubulin

29 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0400481101

Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0400481101

FHIT loss of function in human primary breast cancer correlates with advanced stage of the disease

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15007172

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Fhit tumor suppressor protein regulates the intracellular concentration of diadenosine triphosphate but not diadenosine tetraphosphate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15007172