Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro (Q24315858)

regulation of cytokine production

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Jingti Deng

1

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Christian H James

2

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Lisa Patel

3

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Alberto Smith

4

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Kevin G Burnand

5

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Hassan Rahmoune

6

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Jonathan R Lamb

7

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Bill Davis

Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice.

8

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language of work or name

English

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publication date

February 2009

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published in

Clinical Science

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volume

116

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page(s)

241-8

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issue

3

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cites work

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Tribbles: novel regulators of cell function; evolutionary aspects

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TRB3 modulates C2C12 differentiation by interfering with Akt activation

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Downregulated CD36 and oxLDL uptake and stimulated ABCA1/G1 and cholesterol efflux as anti-atherosclerotic mechanisms of interleukin-10.

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Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia

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Tribbles: a family of kinase-like proteins with potent signalling regulatory function.

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Regulation of expression and signalling modulator function of mammalian tribbles is cell-type specific

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Monocyte recruitment and foam cell formation in atherosclerosis

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Fibrates upregulate TRB3 in lymphocytes independent of PPAR alpha by augmenting CCAAT/enhancer-binding protein beta (C/EBP beta) expression.

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Introduction. Lipid oxidation products and atherosclerosis

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Inflammation, atherosclerosis, and coronary artery disease

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cAMP-induced Interleukin-10 promoter activation depends on CCAAT/enhancer-binding protein expression and monocytic differentiation

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Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

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Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways

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Role of interleukin-17 and interleukin-17-induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease

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Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells

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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

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TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism

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Novel candidate genes in unstable areas of human atherosclerotic plaques.

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Expression of Interleukin-10 in Advanced Human Atherosclerotic Plaques

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Serum level of the antiinflammatory cytokine interleukin-10 is an important prognostic determinant in patients with acute coronary syndromes.

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Interleukin-10 suppresses tissue factor expression in lipopolysaccharide-stimulated macrophages via inhibition of Egr-1 and a serum response element/MEK-ERK1/2 pathway

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

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Interleukin-10 enhances the oxidized LDL-induced foam cell formation of macrophages by antiapoptotic mechanisms.

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Genetic Variation in the Interleukin-10 Gene Promoter and Risk of Coronary and Cerebrovascular Events: The PROSPER Study

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Drug-induced immunomodulation to affect the development and progression of atherosclerosis: a new opportunity?

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Inflammatory Cytokines and Cardiovascular Disease

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