Human DJ-1 and its homologs are novel glyoxalases (Q24316421)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903190

glyoxalase (glycolic acid-forming) activity

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1990422

Parkinsonism associated deglycase

1 reference

glyoxal metabolic process

1 reference

Parkinson disease (autosomal recessive, early onset) 7

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Glutathione-independent glyoxalase DJR-1.2 CELE_C49G7.11

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Glutathione-independent glyoxalase DJR-1.1 CELE_B0432.2

1 reference

author name string

Ju-young Lee

1

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Jeeyeon Song

2

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Kyu Kwon

3

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Sumi Jang

4

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Chayeon Kim

5

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Kwanghee Baek

6

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Jeongho Kim

7

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Chankyu Park

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

8

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language of work or name

English

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publication date

15 July 2012

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published in

Human Molecular Genetics

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volume

21

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issue

14

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page(s)

3215-25

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cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

DJ-1 has a role in antioxidative stress to prevent cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Crosslinking of alpha-synuclein by advanced glycation endproducts--an early pathophysiological step in Lewy body formation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Advanced protein glycosylation in diabetes and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer's disease brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Hsp31 of Escherichia coli K-12 is glyoxalase III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent Manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

The cytotoxic mechanism of glyoxal involves oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

The atomic resolution crystal structure of the YajL (ThiJ) protein from Escherichia coli: a close prokaryotic homologue of the Parkinsonism-associated protein DJ-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells--protection by carbonyl scavengers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

Increase in three alpha,beta-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155

inferred from DOI database lookup

7 January 2021

based on heuristic

Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS155