LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation (Q24316935)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19255442%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

title

LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation (English)

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22 January 2020

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positive regulation of lymphocyte chemotaxis

1 reference

Gene Ontology release 2020-05-02

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Serine/threonine kinase 10

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regulation of lymphocyte migration

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Serine/threonine kinase 10

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author

Hajime Karasuyama

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19255442%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

author name string

Natalya V Belkina

1

1 reference

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22 January 2020

Yin Liu

2

1 reference

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22 January 2020

Jian-Jiang Hao

3

1 reference

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22 January 2020

Stephen Shaw

5

1 reference

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22 January 2020

language of work or name

English

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publication date

2 March 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19255442%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

22 January 2020

published in

1 reference

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22 January 2020

volume

106

1 reference

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22 January 2020

issue

12

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22 January 2020

page(s)

4707-4712

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Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

22 January 2020

cites work

1 reference

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LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes

19 March 2017

1 reference

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19 March 2017

1 reference

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Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660762

ERM proteins and merlin: integrators at the cell cortex

19 March 2017

1 reference

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Protein kinase recognition sequence motifs

7 April 2017

1 reference

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Enrichment of distinct microfilament-associated and GTP-binding-proteins in membrane/microvilli fractions from lymphoid cells

7 April 2017

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The actin cytoskeleton in T cell activation

27 September 2017

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Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells

27 September 2017

1 reference

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Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis

27 September 2017

1 reference

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Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity

27 September 2017

1 reference

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Ezrin/radixin/moesin: versatile controllers of signaling molecules and of the cortical cytoskeleton

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660762

The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660762

Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660762

A single pair of acidic residues in the kinase major groove mediates strong substrate preference for P-2 or P-5 arginine in the AGC, CAMK, and STE kinase families

27 September 2017

1 reference

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A rapid method for determining protein kinase phosphorylation specificity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660762

Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660762

Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660762

Kinase peptide specificity: improved determination and relevance to protein phosphorylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660762

Molecular mechanisms of zinc-dependent leukocyte adhesion involving the urokinase receptor and beta2-integrins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660762

Molecular cloning and characterization of a novel putative STE20-like kinase in guinea pigs.

27 September 2017

1 reference

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How do protein kinases recognize their substrates?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660762

Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2660762

Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0805963106

Chemokine stimulation of human peripheral blood T lymphocytes induces rapid dephosphorylation of ERM proteins, which facilitates loss of microvilli and polarization

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0805963106

ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation

21 January 2018

1 reference

12 December 2020

Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytes

1 reference

12 December 2020

The urokinase receptor is a major vitronectin-binding protein on endothelial cells

1 reference

12 December 2020

Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence

1 reference

12 December 2020

Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures

1 reference

12 December 2020

Aurora-B and Rho-kinase/ROCK, the two cleavage furrow kinases, independently regulate the progression of cytokinesis: possible existence of a novel cleavage furrow kinase phosphorylates ezrin/radixin/moesin (ERM)

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0805963106

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19255442%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

ADS bibcode

2009PNAS..106.4707B

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19255442%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

2 references