A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism (Q24317131)

1

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Josee Gauthier

2

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Philip Cheng

3

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Denis Gris

5

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Oskar Laur

6

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John Pierson

7

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Sean Wentworth

8

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Andrea G Nackley

9

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William Maixner

10

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Luda Diatchenko

https://scigraph.springernature.com/pub.10.1186/1744-8069-6-33

11

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language of work or name

English

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publication date

2010

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published in

Molecular Pain

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volume

6

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issue

1

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page(s)

33

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exact match

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cites work

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Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene

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Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia

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Activation of μ opioid receptors inhibits transient high- and low-threshold Ca 2+ currents, but spares a sustained current

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Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene

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Opioid tolerance and hyperalgesia

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Discovery of naturally occurring splice variants of the rat histamine H3 receptor that act as dominant-negative isoforms

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Techniques: GPCR assembly, pharmacology and screening by flow cytometry.

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Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal

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A murine model of opioid-induced hyperalgesia

27 September 2017

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The dopamine D3 receptor interacts with itself and the truncated D3 splice variant d3nf: D3-D3nf interaction causes mislocalization of D3 receptors

27 September 2017

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Antagonists of excitatory opioid receptor functions enhance morphine's analgesic potency and attenuate opioid tolerance/dependence liability

27 September 2017

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27 September 2017

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Dissociation between the inhibitory and stimulatory effects of opioid peptides on cAMP formation in SK-N-SH neuroblastoma cells

30 May 2018

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Morphine produces a biphasic modulation of substance P release from cultured dorsal root ganglion neurons

30 May 2018

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30 May 2018

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Membrane conductances and opioid receptor subtypes

30 May 2018

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Morphine produces a multiphasic effect on the release of substance P from rat trigeminal nucleus slices by activating different opioid receptor subtypes

30 May 2018

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Multiphasic effect of morphine on the release of substance P from rat trigeminal nucleus slices

30 May 2018

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Uptake of morphine and nalorphine by isolated rat hepatocytes

30 May 2018

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Ultra-low-dose naloxone suppresses opioid tolerance, dependence and associated changes in mu opioid receptor-G protein coupling and Gbetagamma signaling

30 May 2018

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Dual regulation by mu, delta and kappa opioid receptor agonists of K+ conductance of DRG neurons and neuroblastoma X DRG neuron hybrid F11 cells

21 January 2018

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Unique isoform of Galpha -interacting protein (RGS-GAIP) selectively discriminates between two Go-mediated pathways that inhibit Ca2+ channels

21 January 2018

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Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia

21 January 2018

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The mu opioid agonist DAMGO stimulates cAMP production in SK-N-SH cells through a PLC-PKC-Ca++ pathway

21 January 2018

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Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions

21 January 2018

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Complex of an active mu-opioid receptor with a cyclic peptide agonist modeled from experimental constraints

21 January 2018

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Transport is not rate-limiting in morphine glucuronidation in the single-pass perfused rat liver preparation.

21 January 2018

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Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine

21 January 2018

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Spinal cord nitric oxide synthase and heme oxygenase limit morphine induced analgesia

21 January 2018

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Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase

21 January 2018

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Low-dose morphine induces hyperalgesia through activation of G alphas, protein kinase C, and L-type Ca 2+ channels in rats

21 January 2018

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Effects of chronic morphine administration on mu opioid receptor-stimulated [35S]GTPgammaS autoradiography in rat brain

21 January 2018

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Opioid receptor regulation in mice.

29 November 2018

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Inhibition of Ca2+ currents by a mu-opioid in a defined subset of rat sensory neurons

29 November 2018

1 reference

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Selective coupling of G protein beta gamma complexes to inhibition of Ca2+ channels

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20525224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Headless splice variant acting as dominant negative calcitonin receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20525224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1744-8069-6-33

0 references

Dimensions Publication ID

1042924137

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Fatcat ID

release_u3ss4rqwujgxjc6kgnc654xnri

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/u3ss4rqwujgxjc6kgnc654xnri