Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice (Q24317631)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1902692

Leucine rich repeat kinase 2

1 reference

regulation of branching morphogenesis of a nerve

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

1 reference

11

M J Farrer

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author name string

B Winner

1

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H L Melrose

2

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C Zhao

3

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K M Hinkle

4

0 references

M Yue

5

0 references

C Kent

6

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A T Braithwaite

7

0 references

S Ogholikhan

8

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R Aigner

9

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J Winkler

10

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F H Gage

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

12

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language of work or name

English

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publication date

March 2011

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published in

Neurobiology of Disease

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volume

41

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issue

3

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page(s)

706-16

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cites work

1 reference

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Discovery of a proneurogenic, neuroprotective chemical

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MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

19 March 2017

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The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

19 March 2017

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

19 March 2017

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

19 March 2017

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

19 March 2017

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Cell therapy in Huntington disease

19 March 2017

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LRRK2 in Parkinson's disease: protein domains and functional insights

19 March 2017

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The Parkinson's complex: parkinsonism is just the tip of the iceberg

19 March 2017

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Doublecortin expression levels in adult brain reflect neurogenesis

19 March 2017

1 reference

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

19 March 2017

1 reference

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Neurogenesis in the adult human hippocampus

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension

19 March 2017

1 reference

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Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

6 April 2017

1 reference

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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

7 April 2017

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Functional neurogenesis in the adult hippocampus

7 April 2017

1 reference

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Structure and function of dendritic spines

7 April 2017

1 reference

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Running enhances neurogenesis, learning, and long-term potentiation in mice

7 April 2017

1 reference

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Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

7 April 2017

1 reference

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Lrrk2 localization in the primate basal ganglia and thalamus: a light and electron microscopic analysis in monkeys

7 April 2017

1 reference

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Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway

27 September 2017

1 reference

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Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms.

27 September 2017

1 reference

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Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

27 September 2017

1 reference

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Hyposmia in G2019S LRRK2-related parkinsonism: clinical and pathologic data.

27 September 2017

1 reference

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Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain.

27 September 2017

1 reference

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Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

27 September 2017

1 reference

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LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study

27 September 2017

1 reference

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Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice.

27 September 2017

1 reference

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The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Exercise builds brain health: key roles of growth factor cascades and inflammation

27 September 2017

1 reference

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Adult hippocampal neurogenesis in depression

27 September 2017

1 reference

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A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Physical activity fails to rescue hippocampal neurogenesis deficits in the R6/2 mouse model of Huntington's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Natural variation and genetic covariance in adult hippocampal neurogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Dopamine depletion impairs precursor cell proliferation in Parkinson disease.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Molecular regulation of dendritic spine shape and function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Some new, simple and efficient stereological methods and their use in pathological research and diagnosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Three-dimensional counting: an accurate and direct method to estimate numbers of cells in sectioned material

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Expression of ezrin radixin moesin proteins in the adult subventricular zone and the rostral migratory stream.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Structural changes associated with progression of motor deficits in spinocerebellar ataxia 17.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Dopaminergic lesion enhances growth factor-induced striatal neuroblast migration.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment

29 November 2018

1 reference

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Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

VEGF is necessary for exercise-induced adult hippocampal neurogenesis

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Delaying the onset of Huntington's in mice

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Post-Natal Origin of Microneurones in the Rat Brain

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3059106

Impact of physical fitness on strategy development in decision-making tasks

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21168496

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Human Wild-Type α-Synuclein Impairs Neurogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21168496

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Premotor Parkinson disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21168496

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NBD.2010.12.008

1 reference

1 reference

1 reference

PubMed publication ID

21168496

1 reference