Mechanism of activation for Zap-70 catalytic activity (Q24318354)

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J Hawkins

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L J Frank

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D Wisniewski

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A Marcy

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

29 October 1996

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published in

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volume

93

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issue

22

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page(s)

12165-70

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cites work

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Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

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Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

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Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling

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ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

19 March 2017

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

19 March 2017

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Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel

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Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

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Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling

19 March 2017

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Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells

19 March 2017

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ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

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Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

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Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif

19 March 2017

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Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

19 March 2017

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19 March 2017

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Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach

7 April 2017

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Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha

27 September 2017

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Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity

27 September 2017

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The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction

27 September 2017

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Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function

27 September 2017

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Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE.

27 September 2017

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Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation

27 September 2017

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The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

Autophosphorylation induces autoactivation and a decrease in the Src homology 2 domain accessibility of the Lyn protein kinase.

27 September 2017

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Expression, characterization, and crystallization of the catalytic core of the human insulin receptor protein-tyrosine kinase domain

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

Autophosphorylation within insulin receptor .beta.-subunits can occur as an intramolecular process

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

Severe combined immunodeficiency with absence of peripheral blood CD8+ T cells due to ZAP-70 deficiency

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

Autophosphorylation activates the soluble cytoplasmic domain of the insulin receptor in an intermolecular reaction

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=37961

Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8901551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8901551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of pp60c-src tyrosine kinase activities using a continuous assay: autoactivation of the enzyme is an intermolecular autophosphorylation process

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8901551