Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A (Q24318654)

5

object named as

King-Song Jeng

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Keigo Machida

6

object named as

Keigo Machida

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author name string

Yung-Chia Chen

1

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Wen-Chi Su

2

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Jing-Ying Huang

3

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Ti-Chun Chao

Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A

4

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language of work or name

English

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publication date

August 2010

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published in

Journal of Virology

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volume

84

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page(s)

7983-93

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issue

16

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cites work

1 reference

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Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication

19 March 2017

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Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft

19 March 2017

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Active cyclin B1-Cdk1 first appears on centrosomes in prophase

19 March 2017

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Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.

19 March 2017

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Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

19 March 2017

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Plk1 promotes nuclear translocation of human Cdc25C during prophase

19 March 2017

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Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

19 March 2017

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A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

19 March 2017

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CD81 Is a Central Regulator of Cellular Events Required for Hepatitis C Virus Infection of Human Hepatocytes

19 March 2017

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Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles

19 March 2017

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Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

19 March 2017

1 reference

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Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

19 March 2017

1 reference

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Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in Hepatitis C virus replicon

19 March 2017

1 reference

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The Isoform of Protein Kinase CKI Is Responsible for Hepatitis C Virus NS5A Hyperphosphorylation

19 March 2017

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Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras

19 March 2017

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Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase

19 March 2017

1 reference

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Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

19 March 2017

1 reference

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Hepatitis C Virus RNA Replication Occurs on a Detergent-Resistant Membrane That Cofractionates with Caveolin-2

19 March 2017

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Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

19 March 2017

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Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees

19 March 2017

1 reference

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Effect of alpha interferon on the hepatitis C virus replicon

19 March 2017

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Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein

19 March 2017

1 reference

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Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B

19 March 2017

1 reference

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The NS5A/NS5 proteins of viruses from three genera of the family flaviviridae are phosphorylated by associated serine/threonine kinases

19 March 2017

1 reference

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Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase

19 March 2017

1 reference

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Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A

19 March 2017

1 reference

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Hepatitis C virus infection

19 March 2017

1 reference

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Efficient initiation of HCV RNA replication in cell culture

19 March 2017

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An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis

19 March 2017

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A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins

19 March 2017

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M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex

19 March 2017

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Phosphate groups as substrate determinants for casein kinase I action

19 March 2017

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Plk1 depletion in nontransformed diploid cells activates the DNA-damage checkpoint

19 March 2017

1 reference

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Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.

27 September 2017

1 reference

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Hepatitis C viral life cycle

27 September 2017

1 reference

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BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

Mutational analysis of hepatitis C virus nonstructural protein 5A: potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli

27 September 2017

1 reference

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Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex

27 September 2017

1 reference

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Peginterferon vs. standard interferon in the treatment of chronic hepatitis C

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

Hepatitis C virus NS5A protein is phosphorylated by casein kinase II.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

Ribavirin in the treatment of hepatitis C.

30 May 2018

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Nuclear translocation of plk1 mediated by its bipartite nuclear localization signal

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916529

29 November 2018

Treatment of hepatitis C

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20534861

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Treatment of hepatitis C

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20534861