{gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice (Q24318989)

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English	{gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice	scientific article

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scholarly article

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{gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice (English)

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Ankyrin repeat domain 49

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GOA release 2020-03-11

positive regulation of transcription, DNA-templated

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GOA release 2020-03-11

2

object named as

Carlos F Barbas

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author name string

C Anthony Blau

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Anna L Bomhoff

3

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Renee Neades

4

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James Yan

5

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Patrick A Navas

6

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Kenneth R Peterson

7

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language of work or name

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publication date

4 November 2005

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Journal of Biological Chemistry

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280

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44

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36642-7

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Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes

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FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes

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Fetal gene reactivation

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Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines

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Analysis of human hemoglobin switching in MEL x human fetal erythroid cell hybrids.

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Controlling signal transduction with synthetic ligands

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A proliferation switch for genetically modified cells

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Targeted expansion of genetically modified bone marrow cells

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LCR-dependent gene expression in beta-globin YAC transgenics: detailed structural studies validate functional analysis even in the presence of fragmented YACs.

1 reference

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21 January 2018

Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants

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In vivo selection using a cell-growth switch

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Exploring strategies for the design of artificial transcription factors: targeting sites proximal to known regulatory regions for the induction of gamma-globin expression and the treatment of sickle cell disease

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Transgenic Cre expression mice for generation of erythroid-specific gene alterations

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Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4

1 reference

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Cloning and characterization of a potential transcriptional activator of human gamma-globin genes

1 reference

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Pharmacologically regulated cell therapy

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Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells.

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5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons

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The role of p22 NF-E4 in human globin gene switching

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5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+Thalassemia

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7 January 2021

based on heuristic

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Sensitive ribonuclease protection assay employing glycogen as a carrier and a single inactivation/precipitation step

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based on heuristic

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Identifiers

10.1074/JBC.M504402200

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