Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL (Q24319030)

GOA release 2020-03-11

Apolipoprotein C1

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lipase inhibitor activity

GOA release 2020-03-11

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GOA release 2020-03-11

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4

Louis M Havekes

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author name string

Jimmy F P Berbée

1

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Caroline C van der Hoogt

2

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Deepa Sundararaman

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Patrick C N Rensen

Journal of Lipid Research

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language of work or name

English

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publication date

February 2005

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published in

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volume

46

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page(s)

297-306

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issue

2

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Cofactor activity of protein components of human very low density lipoproteins in the hydrolysis of triglycerides by lipoproteins lipase from different sources

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Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins

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COOH-terminal disruption of lipoprotein lipase in mice is lethal in homozygotes, but heterozygotes have elevated triglycerides and impaired enzyme activity.

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Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice

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Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver

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Apolipoprotein E is resistant to intracellular degradation in vitro and in vivo. Evidence for retroendocytosis

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Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity

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Very low density lipoprotein (VLDL) receptor-deficient mice have reduced lipoprotein lipase activity. Possible causes of hypertriglyceridemia and reduced body mass with VLDL receptor deficiency

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Apolipoprotein CI deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl ester transfer protein (CETP) in CETP transgenic/ApoCI-knocked out mice.

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Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein C1

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In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway

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Overexpression of apoC-I in apoE-null mice: severe hypertriglyceridemia due to inhibition of hepatic lipase

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