Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease (Q24319830)

Parkinsonism associated deglycase

GOA release 2020-03-11

1 reference

negative regulation of oxidative stress-induced cell death

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Beisha Tang

1

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Hui Xiong

2

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Ping Sun

3

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Yuhu Zhang

4

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Danling Wang

5

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Zhengmao Hu

6

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Zanhua Zhu

7

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Hong Ma

8

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Qian Pan

9

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Jia-Hui Xia

10

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Kun Xia

11

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Zhuohua Zhang

The role of pathogenic DJ-1 mutations in Parkinson's disease.

12

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language of work or name

English

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publication date

1 June 2006

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published in

Human Molecular Genetics

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volume

15

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issue

11

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page(s)

1816-25

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cites work

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7 January 2021

Novel PINK1 mutations in early-onset parkinsonism

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PINK1 mutations are associated with sporadic early-onset parkinsonism

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Genetics of parkin-linked disease.

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Causes of Parkinson's disease: genetics of DJ-1

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7 January 2021

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

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7 January 2021

Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients

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7 January 2021

Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress

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7 January 2021

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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7 January 2021

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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7 January 2021

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

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7 January 2021

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

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7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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7 January 2021

Alpha-synuclein in Lewy bodies

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7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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7 January 2021

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

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7 January 2021

DJ-1 has a role in antioxidative stress to prevent cell death

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7 January 2021

Parkinson's disease. First of two parts

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7 January 2021

Parkinson's disease. Second of two parts

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7 January 2021

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

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7 January 2021

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

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7 January 2021

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

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7 January 2021

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

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7 January 2021

The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

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7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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7 January 2021

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression

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7 January 2021

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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7 January 2021

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

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7 January 2021

Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease

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7 January 2021

Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function

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7 January 2021

Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice

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7 January 2021

Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

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7 January 2021

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

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7 January 2021

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

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7 January 2021

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.

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7 January 2021

A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

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7 January 2021

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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7 January 2021

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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7 January 2021

Molecular Pathways of Neurodegeneration in Parkinson's Disease

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7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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7 January 2021

RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization

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7 January 2021

DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function

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7 January 2021

Mutation in PITX2 is associated with ring dermoid of the cornea

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7 January 2021

The biochemistry of Parkinson's disease

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7 January 2021

Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism

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7 January 2021

Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes.

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7 January 2021

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

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7 January 2021