The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module (Q24319910)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0061578

CYLD lysine 63 deubiquitinase

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negative regulation of NIK/NF-kappaB signaling

GOA release 2020-03-11

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GOA release 2020-03-11

author

David Komander

1

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Alan Ashworth

6

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Christopher J Lord

object named as

Christopher J Lord

2

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author name string

Hartmut Scheel

3

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Sally Swift

4

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Kay Hofmann

5

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David Barford

TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases

7

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language of work or name

English

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publication date

29 February 2008

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published in

Molecular Cell

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volume

29

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issue

4

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page(s)

451-64

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cites work

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Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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