MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines (Q24320171)

peptidyl-serine phosphorylation

GOA release 2020-03-11

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GOA release 2020-03-11

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Carol A Chrestensen

1

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Jacquelyn K Shuman

2

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Andrew Eschenroeder

3

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Mark Worthington

4

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Hermann Gram

5

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Thomas W Sturgill

Journal of Biological Chemistry

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language of work or name

English

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publication date

16 February 2007

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published in

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volume

282

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issue

7

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page(s)

4243-52

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cites work

Translational control of the proteome: relevance to cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Molecular characterization of the t(3;9) associated with immortalization in the MCF10A cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Herceptin: mechanisms of action and resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

A case study in misidentification of cancer cell lines: MCF-7/AdrR cells (re-designated NCI/ADR-RES) are derived from OVCAR-8 human ovarian carcinoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Drosophila Lk6 kinase controls phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Focus on breast cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

CSF-1 activates MAPK-dependent and p53-independent pathways to induce growth arrest of hormone-dependent human breast cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

MSK1 activity is controlled by multiple phosphorylation sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

The emerging roles of translation factor eIF4E in the nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Intestinal epithelial cell differentiation involves activation of p38 mitogen-activated protein kinase that regulates the homeobox transcription factor CDX2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Features in the N and C termini of the MAPK-interacting kinase Mnk1 mediate its nucleocytoplasmic shuttling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Characterization of new estrogen receptor destabilizing compounds: effects on estrogen-sensitive and tamoxifen-resistant breast cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Proteasome inhibitor bortezomib increases PTEN expression and enhances trastuzumab-induced growth inhibition in trastuzumab-resistant cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Mnk is a negative regulator of cap-dependent translation in Aplysia neurons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Hyperexpression of mitogen-activated protein kinase in human breast cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021

Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607368200

7 January 2021