SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1 (Q24321934)

1

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G D Gish

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G Mbamalu

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N N Iscove

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T Pawson

Journal of Biological Chemistry

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language of work or name

English

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publication date

31 October 1997

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published in

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volume

272

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page(s)

27804-11

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issue

44

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cites work

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NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

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Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death

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Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites

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The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

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Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

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HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

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MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

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Modular binding domains in signal transduction proteins

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

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7 January 2021