Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates (Q24322903)

1

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Anjanabha Saha

2

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Steven Lewis

3

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Raymond J Deshaies

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification

5

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language of work or name

English

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publication date

25 November 2009

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published in

Cell

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volume

139

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issue

5

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page(s)

957-68

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cites work

1 reference

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Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

19 March 2017

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UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

19 March 2017

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A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate

19 March 2017

1 reference

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The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site

19 March 2017

1 reference

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The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

19 March 2017

1 reference

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Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1

19 March 2017

1 reference

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MUSCLE: multiple sequence alignment with high accuracy and high throughput

19 March 2017

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Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

19 March 2017

1 reference

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Electrostatics of nanosystems: application to microtubules and the ribosome

19 March 2017

1 reference

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Recognition of the polyubiquitin proteolytic signal

19 March 2017

1 reference

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Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

19 March 2017

1 reference

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Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

19 March 2017

1 reference

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

19 March 2017

1 reference

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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

19 March 2017

2 references

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19 March 2017

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RING domain E3 ubiquitin ligases

27 September 2017

1 reference

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Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.

19 March 2017

1 reference

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Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.

19 March 2017

1 reference

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The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain

19 March 2017

1 reference

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The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

19 March 2017

1 reference

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Functional and physical characterization of the cell cycle ubiquitin-conjugating enzyme CDC34 (UBC3). Identification of a functional determinant within the tail that facilitates CDC34 self-association

19 March 2017

1 reference

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E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer

19 March 2017

1 reference

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

19 March 2017

1 reference

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

19 March 2017

1 reference

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Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome

19 March 2017

1 reference

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Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804849

The Jpred 3 secondary structure prediction server

19 March 2017

1 reference

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A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

7 April 2017

1 reference

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

7 April 2017

1 reference

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Macromolecular modeling with rosetta

7 April 2017

1 reference

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Fundamental aspects of protein-protein association kinetics

7 April 2017

1 reference

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Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation

27 September 2017

1 reference

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Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail

27 September 2017

1 reference

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Role of ubiquitin- and Ubl-binding proteins in cell signaling

27 September 2017

1 reference

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Nedd8 on cullin: building an expressway to protein destruction.

27 September 2017

1 reference

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Electrostatic aspects of protein-protein interactions.

27 September 2017

1 reference

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An essential domain within Cdc34p is required for binding to a complex containing Cdc4p and Cdc53p in Saccharomyces cerevisiae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804849

A chimeric ubiquitin conjugating enzyme that combines the cell cycle properties of CDC34 (UBC3) and the DNA repair properties of RAD6 (UBC2): implications for the structure, function and evolution of the E2s

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804849

Ubiquitin as a degradation signal

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804849

Fruitful and futile encounters along the association reaction between proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804849

Electrostatic rate enhancement and transient complex of protein-protein association

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804849

High-level expression and purification of recombinant SCF ubiquitin ligases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804849

Identification of a portable determinant of cell cycle function within the carboxyl-terminal domain of the yeast CDC34 (UBC3) ubiquitin conjugating (E2) enzyme

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804849

Sequential E2s drive polyubiquitin chain assembly on APC targets

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804849

Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804849

In vitro reconstitution of SCF substrate ubiquitination with purified proteins

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2804849

Interaction of barnase with its polypeptide inhibitor barstar studied by protein engineering

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19945379

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rapid, electrostatically assisted association of proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19945379

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of apoptosis and cytokinesis by the anti-apoptotic E2/E3 ubiquitin-ligase BRUCE

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19945379

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2009.10.030

1 reference

1 reference

1 reference

PubMed publication ID

19945379

1 reference