Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4 (Q24323265)

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H Yu

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S H Liu

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F M Brodsky

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B M Peterlin

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

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language of work or name

English

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publication date

May 1998

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published in

Immunity

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volume

8

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page(s)

647-56

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issue

5

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cites work

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Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation

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HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

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Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection

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Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pits

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7 January 2021

Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.

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The role of Nef in the replication cycle of the human and simian immunodeficiency viruses

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Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene

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Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys

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The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit

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Human immunodeficiency virus type 1 envelope protein endocytosis mediated by a highly conserved intrinsic internalization signal in the cytoplasmic domain of gp41 is suppressed in the presence of the Pr55gag precursor protein

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Nef-mediated clathrin-coated pit formation

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

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Roles for a cytoplasmic tyrosine and tyrosine kinase activity in the interactions of Neu receptors with coated pits

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Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.

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Bovine papillomavirus E5 oncoprotein binds to the 16K component of vacuolar H(+)-ATPases

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7 January 2021

Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

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The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

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HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

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Myristoylation-dependent binding of HIV-1 Nef to CD4.

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Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

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Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

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Linking cargo to vesicle formation: receptor tail interactions with coat proteins.

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Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes

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Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1.

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A dominant-negative clathrin mutant differentially affects trafficking of molecules with distinct sorting motifs in the class II major histocompatibility complex (MHC) pathway

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CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.

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Legitimate and illegitimate cleavage of human immunodeficiency virus glycoproteins by furin

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Interaction of endocytic signals from the HIV-1 envelope glycoprotein complex with members of the adaptor medium chain family

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Immunopathogenesis of HIV infection

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Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection

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Molecular biology and function of CD4 and CD8

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The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides

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7 January 2021

Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.

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7 January 2021

CD4: collaborator in immune recognition and HIV infection

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7 January 2021

Nef-CD4 physical interaction sensed with the yeast two-hybrid system

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7 January 2021

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

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7 January 2021

Nef proteins encoded by human and simian immunodeficiency viruses induce the accumulation of endosomes and lysosomes in human T cells

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7 January 2021

Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques

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7 January 2021

Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef.

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7 January 2021

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-Iiodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

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7 January 2021

Structure, function and regulation of the vacuolar (H+)-ATPase

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7 January 2021

HIV accessory proteins: leading roles for the supporting cast.

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7 January 2021

In vivo phosphorylation of adaptors regulates their interaction with clathrin

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7 January 2021

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

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7 January 2021