CASK Functions as a Mg2+-independent neurexin kinase (Q24323323)

protein serine/threonine kinase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Thomas C. Südhof

6

0 references

Henning Urlaub

3

0 references

Reinhard Jahn

5

0 references

Gleb Bourenkov

object named as

Gleb P Bourenkov

4

0 references

Markus C Wahl

object named as

Markus C Wahl

7

0 references

Manu Sharma

2

object named as

Manu Sharma

0 references

author name string

Konark Mukherjee

Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins

1

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language of work or name

English

0 references

publication date

18 April 2008

0 references

published in

Cell

0 references

volume

133

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issue

2

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page(s)

328-39

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cites work

1 reference

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CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein

19 March 2017

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Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses

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Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells

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Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin

19 March 2017

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Deletion of CASK in mice is lethal and impairs synaptic function

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Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition

19 March 2017

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19 March 2017

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A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels

19 March 2017

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Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK

19 March 2017

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19 March 2017

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Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells

19 March 2017

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19 March 2017

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CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

19 March 2017

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Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex

19 March 2017

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Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis

19 March 2017

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Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

19 March 2017

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Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport

19 March 2017

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Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2

19 March 2017

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19 March 2017

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7 April 2017

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Ba/F3 cells and their use in kinase drug discovery

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter

27 September 2017

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The CASK/Lin-2 Drosophila homologue, Camguk, could play a role in epithelial patterning and in neuronal targeting.

27 September 2017

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27 September 2017

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hCASK and hDlg associate in epithelia, and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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30 May 2018

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30 May 2018

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Activity-dependent gating of CaMKII autonomous activity by Drosophila CASK.

29 November 2018

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Camguk/CASK enhances Ether-á-go-go potassium current by a phosphorylation-dependent mechanism.

29 November 2018

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Drosophila CAKI/CMG protein, a homolog of human CASK, is essential for regulation of neurotransmitter vesicle release.

29 November 2018

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CASK and protein 4.1 support F-actin nucleation on neurexins

29 November 2018

1 reference

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ATP regulation of type 1 inositol 1,4,5-trisphosphate receptor channel gating by allosteric tuning of Ca(2+) activation.

29 November 2018

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Intracellular Mg2+ surge follows Ca2+ increase during depolarization in cultured neurons

29 November 2018

1 reference

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The location of human CASK at Xp11.4 identifies this gene as a candidate for X-linked optic atrophy.

29 November 2018

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Depolarization triggers intracellular magnesium surge in cultured dorsal root ganglion neurons.

29 November 2018

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29 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/18423203

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Glutamate-induced increases in intracellular free Mg2+ in cultured cortical neurons

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18423203

inferred from PubMed ID database lookup

12 December 2020

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The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

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Identifiers

DOI

10.1016/J.CELL.2008.02.036

1 reference

1 reference

1 reference

PubMed publication ID

18423203

1 reference