Interaction between the retinoblastoma protein and the oncoprotein MDM2 (Q24323385)

positive regulation of cell population proliferation

GOA release 2020-03-11

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GOA release 2020-03-11

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Z X Xiao

1

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J Chen

2

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A J Levine

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N Modjtahedi

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J Xing

5

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W R Sellers

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D M Livingston

The p53 tumour suppressor gene

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language of work or name

English

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publication date

22 June 1995

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published in

Nature

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volume

375

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issue

6533

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page(s)

694-8

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cites work

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7 January 2021

Tumor suppressor genes

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7 January 2021

Cooperative tumorigenic effects of germline mutations in Rb and p53

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7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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7 January 2021

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

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7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

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7 January 2021

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

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7 January 2021

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides

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7 January 2021

Mapping of the p53 and mdm-2 interaction domains

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7 January 2021

Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+

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7 January 2021

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

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7 January 2021

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

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7 January 2021

Identification of a growth suppression domain within the retinoblastoma gene product

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7 January 2021

Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression

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7 January 2021

The transcription factor E2F-1 is a downstream target of RB action

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7 January 2021

Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members

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7 January 2021

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation

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7 January 2021

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter

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7 January 2021

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

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7 January 2021

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

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7 January 2021

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

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7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

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7 January 2021

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

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7 January 2021

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

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7 January 2021