Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a (Q24324559)

Cyclin A2

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HRas proto-oncogene, GTPase

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Cyclin dependent kinase 2

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Cyclin dependent kinase inhibitor 1A

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tumor protein p53

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cyclin dependent kinase inhibitor 2A

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Ras protein signal transduction

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1 reference

M Serrano

1

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author name string

A W Lin

2

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M E McCurrach

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D Beach

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S W Lowe

Investigation of the role of G1/S cell cycle mediators in cellular senescence

5

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language of work or name

English

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publication date

7 March 1997

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published in

Cell

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volume

88

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page(s)

593-602

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issue

5

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cites work

1 reference

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7 January 2021

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

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7 January 2021

Increased activity of p53 in senescing fibroblasts

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Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

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Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes

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The ras gene family and human carcinogenesis

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Radiation-induced cell cycle arrest compromised by p21 deficiency

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Signalling pathways: jack of all cascades

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Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes

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7 January 2021

The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation

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7 January 2021

In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes.

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CDC25 phosphatases as potential human oncogenes

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Cdc25 cell-cycle phosphatase as a target of c-myc

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Overexpression of plasminogen activator inhibitor type-1 in senescent fibroblasts from normal subjects and those with Werner syndrome

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7 January 2021

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

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7 January 2021

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

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The serial cultivation of human diploid cell strains

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Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest

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Function of a human cyclin gene as an oncogene

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Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene

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Strong effects of 5-azacytidine on the in vitro lifespan of human diploid fibroblasts.

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7 January 2021

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

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Cooperation between oncogenes

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Tumor spectrum analysis in p53-mutant mice

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Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

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Lessons from hereditary colorectal cancer

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p53: puzzle and paradigm

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

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Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

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7 January 2021

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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7 January 2021

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

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Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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7 January 2021

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

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Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

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Differential growth state-dependent regulation of plasminogen activator inhibitor type-1 expression in senescent IMR-90 human diploid fibroblasts

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Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

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7 January 2021

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

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7 January 2021

Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent

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7 January 2021

Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

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7 January 2021

Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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7 January 2021

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

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7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

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Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts

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Inhibitors of mammalian G1 cyclin-dependent kinases

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7 January 2021

Origins of G1 arrest in senescent human fibroblasts

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Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.

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7 January 2021

Role of ceramide in cellular senescence

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7 January 2021

The multistep nature of cancer

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7 January 2021

The retinoblastoma protein and cell cycle control

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7 January 2021

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

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Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation

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7 January 2021

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

123989

123989

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference