Binding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef protein (Q24324674)

1

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K J Dunn

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G K Pei

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M K Chakrabarty

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G Heidecker

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J A Lautenberger

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K P Samuel

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

19 June 1998

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published in

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volume

273

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issue

25

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page(s)

15727-33

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cites work

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Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase

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Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor

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Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes

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The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation.

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

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Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

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HIV-1 Nef protein inhibits the recruitment of AP-1 DNA-binding activity in human T-cells

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Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys

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The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

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Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.

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Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail

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Nef-CD4 physical interaction sensed with the yeast two-hybrid system

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Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes

21 January 2018

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A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity

21 January 2018

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The HIV nef protein associates with protein kinase C theta

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In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase

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Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix.

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Identification of cellular proteins that bind to the human immunodeficiency virus type 1 nef gene product in vitro: a role for myristylation

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Nef proteins of the human immunodeficiency viruses (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV) are structurally similar to leucine zipper transcriptional activation factors

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Rapid and efficient site-specific mutagenesis without phenotypic selection

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Polymorphism of the 3' open reading frame of the virus associated with the acquired immune deficiency syndrome, human T-lymphotropic virus type III.

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

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Heterogeneity of Nef proteins in cells infected with human immunodeficiency virus type 1.

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

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Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

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Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

21 January 2018

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

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Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes

21 January 2018

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Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation

21 January 2018

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Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation

21 January 2018

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Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

21 January 2018

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

21 January 2018

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Activation of Raf as a result of recruitment to the plasma membrane

21 January 2018

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The 3'-orf protein of human immunodeficiency virus shows structural homology with the phosphorylation domain of human interleukin-2 receptor and the ATP-binding site of the protein kinase family

21 January 2018

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Cellular distribution of HIV type 1 Nef protein: identification of domains in Nef required for association with membrane and detergent-insoluble cellular matrix

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Diagnosis of central nervous system complications in HIV-infected patients

21 January 2018

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HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

21 January 2018

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The HIV-1 nef gene acts as a positive viral infectivity factor

21 January 2018

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Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

21 January 2018

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7 January 2021

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

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https://api.crossref.org/works/10.1074%2FJBC.273.25.15727

7 January 2021

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

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https://api.crossref.org/works/10.1074%2FJBC.273.25.15727

7 January 2021

The HIV-1 nef gene product is associated with phosphorylation of a 46 kD cellular protein

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7 January 2021

Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein

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7 January 2021