Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection (Q24329155)

viral entry into host cell

GOA release 2020-03-11

1 reference

NPC intracellular cholesterol transporter 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

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Claire Marie Filone

6

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John Misasi

object named as

John Misasi

2

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Lisa Hensley

7

object named as

Lisa Hensley

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Kartik Chandran

10

object named as

Kartik Chandran

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author name string

Marceline Côté

1

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Tao Ren

3

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Anna Bruchez

4

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Kyungae Lee

5

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Qi Li

8

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Daniel Ory

9

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James Cunningham

describes a project that uses

11

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language of work or name

English

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publication date

15 September 2011

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published in

Nature

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volume

477

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issue

7364

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page(s)

344-8

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ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3230319/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda

19 March 2017

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Rapid detection protocol for filoviruses

19 March 2017

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Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner

19 March 2017

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Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

19 March 2017

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19 March 2017

Viral membrane fusion

1 reference

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Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking

19 March 2017

1 reference

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Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

19 March 2017

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A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking

19 March 2017

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Cell adhesion-dependent membrane trafficking of a binding partner for the ebolavirus glycoprotein is a determinant of viral entry

27 September 2017

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Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity

27 September 2017

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A forward genetic strategy reveals destabilizing mutations in the Ebolavirus glycoprotein that alter its protease dependence during cell entry

27 September 2017

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Lysosomal degradation of membrane lipids

27 September 2017

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The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell binding

27 September 2017

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Cholesterol accumulation by macrophages impairs phagosome maturation

27 September 2017

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Immunopathology of highly virulent pathogens: insights from Ebola virus

27 September 2017

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Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity

27 September 2017

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Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events

27 September 2017

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Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor

27 September 2017

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Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein

27 September 2017

1 reference

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Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening

27 September 2017

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Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

27 September 2017

1 reference

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Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events

27 September 2017

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A transient three-plasmid expression system for the production of high titer retroviral vectors

27 September 2017

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Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis

27 September 2017

1 reference

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Lysobisphosphatidic acid controls endosomal cholesterol levels

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10380

The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10380

Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10380

Identification of HSP60 as a Primary Target ofo-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10380

21 January 2018

Identifiers

DOI

10.1038/NATURE10380

1 reference

Dimensions Publication ID

581473

1000611318

0 references

581473

1 reference

1 reference

1 reference