Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations (Q24336678)

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Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations

Language	Label	Description	Also known as
English	Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations	scientific article	Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations

Statements

scholarly article

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Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations (English)

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mitochondrial DNA

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DNA polymerase gamma, catalytic subunit

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GOA release 2020-03-11

DNA polymerase gamma 2, accessory subunit

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GOA release 2020-03-11

positive regulation of DNA-directed DNA polymerase activity

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GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

Young-Sam Lee

1

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W Dexter Kennedy

2

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Y Whitney Yin

3

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language of work or name

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publication date

16 October 2009

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139

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2

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312-24

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The EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

19 March 2017

Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

19 March 2017

Functional human mitochondrial DNA polymerase gamma forms a heterotrimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

19 March 2017

Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

19 March 2017

Premature ageing in mice expressing defective mitochondrial DNA polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

19 March 2017

Structural Basis for DNA-Hairpin Promoter Recognition by the Bacteriophage N4 Virion RNA Polymerase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

19 March 2017

Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase gamma, Pol gamma B, functions as a homodimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

19 March 2017

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

19 March 2017

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

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19 March 2017

The CCP4 suite: programs for protein crystallography

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19 March 2017

Macromolecular TLS refinement in REFMAC at moderate resolutions

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19 March 2017

Implementation of molecular replacement in AMoRe

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19 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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19 March 2017

Mapping the protein universe

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19 March 2017

Sequence and organization of the human mitochondrial genome

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19 March 2017

Mitochondrial disorders

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19 March 2017

Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

19 March 2017

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

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7 April 2017

155th ENMC workshop: polymerase gamma and disorders of mitochondrial DNA synthesis, 21-23 September 2007, Naarden, The Netherlands

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27 September 2017

Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders

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27 September 2017

A brief overview of mechanisms of mitochondrial toxicity from NRTIs

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27 September 2017

A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

27 September 2017

Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

27 September 2017

The common A467T mutation in the human mitochondrial DNA polymerase (POLG) compromises catalytic efficiency and interaction with the accessory subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

27 September 2017

Functional defects due to spacer-region mutations of human mitochondrial DNA polymerase in a family with an ataxia-myopathy syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

27 September 2017

A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factor

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

27 September 2017

DNA polymerase fidelity: kinetics, structure, and checkpoints

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

27 September 2017

Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

27 September 2017

Mutations of mitochondrial DNA polymerase gammaA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

27 September 2017

Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

27 September 2017

Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

27 September 2017

Replication of animal mitochondrial DNA.

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27 September 2017

Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

27 September 2017

Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7.

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27 September 2017

Deoxyribonucleic acid polymerase of bacteriophage T7. Purification and properties of the phage-encoded subunit, the gene 5 protein

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27 September 2017

DNA polymerase III holoenzyme of Escherichia coli. Purification and resolution into subunits

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27 September 2017

Expression, purification, and initial kinetic characterization of the large subunit of the human mitochondrial DNA polymerase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018533

30 May 2018

Escherichia coli thioredoxin stabilizes complexes of bacteriophage T7 DNA polymerase and primed templates

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30 May 2018

A mitochondrial DNA polymerase from embryos of Drosophila melanogaster. Purification, subunit structure, and partial characterization

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30 May 2018

Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids

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29 November 2018

The accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome function

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29 November 2018

POLG mutations in Alpers syndrome

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29 November 2018

Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase-gammaA.

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29 November 2018

The structural mechanism of translocation and helicase activity in T7 RNA polymerase.

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29 November 2018

Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication.

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29 November 2018

Producing selenomethionine-labeled proteins with a baculovirus expression vector system

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12 December 2020

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Exonuclease proofreading by human mitochondrial DNA polymerase

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https://pubmed.ncbi.nlm.nih.gov/19837034

12 December 2020

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Processing of X-ray diffraction data collected in oscillation mode

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https://pubmed.ncbi.nlm.nih.gov/19837034

12 December 2020

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Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity

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12 December 2020

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Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.

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OpenCitations bibliographic resource ID

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