The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional (Q24336719)

GOA release 2020-03-11

dihydrofolate reductase

1 reference

tetrahydrofolate metabolic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

5

Christine Loscher

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author name string

Gráinne McEntee

1

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Stefano Minguzzi

2

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Kirsty O'Brien

3

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Nadia Ben Larbi

4

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Christine Loscher

5

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Ciarán O'Fágáin

6

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Anne Parle-McDermott

Proceedings of the National Academy of Sciences of the United States of America

7

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language of work or name

English

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publication date

13 September 2011

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published in

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volume

108

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issue

37

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page(s)

15157-62

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cites work

The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Nucleotide sequence of the human NAD-dependent methylene tetrahydrofolate dehydrogenase-cyclohydrolase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Isolation of rat dihydrofolate reductase gene and characterization of recombinant enzyme

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Dual targeting of mitochondrial proteins: mechanism, regulation and function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Cancer research: from folate antagonism to molecular targets

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Systematic recovery and analysis of full-ORF human cDNA clones

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Identification of critical amino acid residues on human dihydrofolate reductase protein that mediate RNA recognition

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Human dihydrofolate reductase gene is located in chromosome 5 and is unlinked to the related pseudogenes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Chromosomal organization of the human dihydrofolate reductase genes: dispersion, selective amplification, and a novel form of polymorphism

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Increase of dihydrofolate reductase activity in cultured mammalian cells after exposure to methotrexate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Isolation of a dihydrofolate reductase-deficient mutant of Escherichia coli

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Chromosomal localization and racial distribution of the polymorphic human dihydrofolate reductase pseudogene (DHFRP1).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Compartmentation of folate-mediated one-carbon metabolism in eukaryotes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Intrinsic resistance to methotrexate of cultured mammalian cells in relation to the inhibition kinetics of their dihydrololate reductases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Distinct roles for Sp1 and E2F sites in the growth/cell cycle regulation of the DHFR promoter

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Translational regulation of the synthesis of dihydrofolate reductase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Regulation of dihydrofolate reductase in human breast cancer cells and in mutant hamster cells transfected with a human dihydrofolate reductase minigene

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Small ubiquitin-like modifier-1 (SUMO-1) modification of thymidylate synthase and dihydrofolate reductase

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1103605108

Molecular cloning, characterization, and regulation of the human mitochondrial serine hydroxymethyltransferase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1103605108

Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1103605108

Folic acid and folates. Preface

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Effect of methotrexate on dihydrofolate reductase activity in methotrexate-resistant human KB cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174580

A cytosolic protein contains a cryptic mitochondrial targeting signal

29 November 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1103605108

Dihydrofolate reductase protein inhibits its own translation by binding to dihydrofolate reductase mRNA sequences within the coding region

21 January 2018

1 reference

12 December 2020

A reassessment of the translation initiation codon in vertebrates

1 reference

12 December 2020

Regulation of dihydrofolate reductase gene expression in mouse fibroblasts during the transition from the resting to growing state

1 reference

12 December 2020

The pattern of evolution of smaller-scale gene duplicates in mammalian genomes is more consistent with neo- than subfunctionalisation

1 reference

12 December 2020

Role of the conserved active site residue tryptophan-24 of human dihydrofolate reductase as revealed by mutagenesis

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1103605108

1 reference

3697553

ADS bibcode

2011PNAS..10815157M

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3697553

1 reference

1 reference

1 reference