FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men (Q24336746)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19696402%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men (English)

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5 February 2020

1 reference

GOA release 2020-03-11

negative regulation of coagulation

1 reference

GOA release 2020-03-11

author

Fotios Drenos

3

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5 February 2020

James H Morrissey

7

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5 February 2020

Stephen E Humphries

9

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5 February 2020

author name string

Helen A Ireland

1

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5 February 2020

Jackie A Cooper

2

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5 February 2020

Jayshree Acharya

4

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5 February 2020

Jacqueline P Mitchell

5

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5 February 2020

Ken A Bauer

6

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5 February 2020

M Peter Esnouf

8

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5 February 2020

language of work or name

English

0 references

publication date

20 August 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19696402%20AND%20SRC:MED&resulttype=core&format=json

Arteriosclerosis, Thrombosis, and Vascular Biology

5 February 2020

published in

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5 February 2020

volume

29

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5 February 2020

issue

11

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5 February 2020

page(s)

1968-1974

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Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function

5 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

Inflammation and the activated protein C anticoagulant pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

The Ser219-->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

Multifunctional specificity of the protein C/activated protein C Gla domain.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

Detection of factor X activation in humans

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

Relationship between markers of activated coagulation, their correlation with inflammation, and association with coronary heart disease (NPHSII).

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

Contribution of polymorphisms in the endothelial protein C receptor gene to soluble endothelial protein C receptor and circulating activated protein C levels, and thrombotic risk.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

Kinetics of human factor VII activation.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775706

Comparison of novel hemostatic factors and conventional risk factors for prediction of coronary heart disease

29 November 2018

1 reference

12 December 2020

A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis

1 reference

12 December 2020

Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis

1 reference

12 December 2020

Studies of the prothrombin activation pathway utilizing radioimmunoassays for the F2/F1 + 2 fragment and thrombin--antithrombin complex

1 reference

12 December 2020

Factor IX is activated in vivo by the tissue factor mechanism

1 reference

12 December 2020

Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation

1 reference

12 December 2020

The effects of quality and timing of venepuncture on markers of blood coagulation in healthy middle-aged men

1 reference

12 December 2020

An enzyme-linked immunosorbent assay (ELISA) for the measurement of activated factor XII (Hageman factor) in human plasma

1 reference

12 December 2020

10.1161/ATVBAHA.109.191551

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19696402%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19696402%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

19696402

1 reference