Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling (Q24338262)

positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

GOA release 2020-03-11

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GOA release 2020-03-11

5

William B Guggino

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author name string

Yun Li

1

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Jerry M Wright

2

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Feng Qian

3

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Gregory G Germino

Journal of Biological Chemistry

4

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language of work or name

English

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publication date

16 December 2005

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published in

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volume

280

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issue

50

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page(s)

41298-306

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Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease

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Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X.

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Calreticulin inhibits repetitive intracellular Ca2+ waves

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Calcium signaling and polycystin-2.

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Fast kinetics of calcium liberation induced in Xenopus oocytes by photoreleased inositol trisphosphate

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Caged inositol 1,4,5-trisphosphate for studying release of Ca2+ from intracellular stores

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Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

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Polycystin-2 is an intracellular calcium release channel

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PKD1 interacts with PKD2 through a probable coiled-coil domain

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

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Specific association of the gene product of PKD2 with the TRPC1 channel

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Identification and characterization of polycystin-2, the PKD2 gene product

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Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex

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Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812.

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Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10

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Differential modulation of SERCA2 isoforms by calreticulin

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Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b

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Ca2+-dependent redox modulation of SERCA 2b by ERp57.

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Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains

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A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.

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Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells

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Secreted alkaline phosphatase: an internal standard for expression of injected mRNAs in the Xenopus oocyte

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Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells

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Do polycystins function as cation channels?

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A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo

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Control of IP(3)-mediated Ca2+ puffs in Xenopus laevis oocytes by the Ca2+-binding protein parvalbumin

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Ca2+ transients associated with openings of inositol trisphosphate-gated channels in Xenopus oocytes.

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PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

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Increased frequency of calcium waves in Xenopus laevis oocytes that express a calcium-ATPase

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Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

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Hypoxia alters biophysical properties of endothelial cells via p38 MAPK- and Rho kinase-dependent pathways.

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[Ca2+]i reduction increases cellular proliferation and apoptosis in vascular smooth muscle cells: relevance to the ADPKD phenotype

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The endothelium in health and disease--a target for therapeutic intervention

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