Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions (Q24338669)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903307

regulation of regulated secretory pathway

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1903305

negative regulation of regulated secretory pathway

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Gene Ontology release 2020-05-02

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calcium-dependent phospholipid binding

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GOA release 2020-03-11

Synaptotagmin I

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GOA release 2020-03-11

author

Thomas C. Südhof

6

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Christian Rosenmund

5

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Ok-Ho Shin

1

object named as

Ok-Ho Shin

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author name string

Jeong-Seop Rhee

2

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Jiong Tang

3

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Shuzo Sugita

Genetic and molecular analysis of the synaptotagmin family

4

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language of work or name

English

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publication date

9 January 2003

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number of pages

10

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published in

Neuron

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volume

37

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issue

1

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page(s)

99-108

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cites work

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Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones

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Ca2+ or Sr2+ partially rescues synaptic transmission in hippocampal cultures treated with botulinum toxin A and C, but not tetanus toxin.

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Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.

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Three-dimensional structure of the complexin/SNARE complex

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Strontium and quantal release of transmitter at the neuromuscular junction

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The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis.

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Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

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Synaptotagmin I functions as a calcium regulator of release probability

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Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1

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Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells

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Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

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The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

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The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes

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Two components of transmitter release at a central synapse

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Properties of synchronous and asynchronous release during pulse train depression in cultured hippocampal neurons

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Localization of synaptotagmin-binding domains on syntaxin.

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Ion selectivities of the Ca(2+) sensors for exocytosis in rat phaeochromocytoma cells

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Distinct Ca2+ and Sr2+ binding properties of synaptotagmins. Definition of candidate Ca2+ sensors for the fast and slow components of neurotransmitter release

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Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins

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The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.

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Cellular localization of synaptotagmin I, II, and III mRNAs in the central nervous system and pituitary and adrenal glands of the rat.

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Complexins: cytosolic proteins that regulate SNAP receptor function

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Strontium as a substitute for calcium in the process of transmitter release at the neuromuscular junction

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Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain

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Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

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Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I

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Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis

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