Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines (Q24339615)

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English	Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines	scientific article

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scholarly article

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Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines (English)

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based on heuristic

inferred from title

cytochrome P450 family 1 subfamily A member 2

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GOA release 2020-03-11

F. Peter Guengerich

3

object named as

F P Guengerich

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author name string

M A Butler

1

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M Iwasaki

2

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F F Kadlubar

4

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language of work or name

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publication date

October 1989

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Proceedings of the National Academy of Sciences of the United States of America

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86

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7696-700

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20

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Occupational cancer of the urinary tract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

19 March 2017

Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

19 March 2017

Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

19 March 2017

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

7 April 2017

The contribution of genetically determined oxidation status to inter-individual variation in phenacetin disposition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

27 September 2017

Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

27 September 2017

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

27 September 2017

Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

27 September 2017

The Primary Aromatic Amines: Their Biological Properties and Structure-Activity Relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

27 September 2017

Effect of Aroclor 1254, phenobarbital, and polycyclic aromatic hydrocarbons on the plasma clearance of caffeine in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

27 September 2017

Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

27 September 2017

Structural elucidation of a mutagenic metabolite of 3-amino-1-methyl-5H-pyrido[4,3-b]indole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Polymorphic metabolism of the carcinogen 2-acetylaminofluorene in human liver microsomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

The P450 gene superfamily: recommended nomenclature.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Specificity of rabbit cytochrome P-450 isozymes involved in the metabolic activation of the food derived mutagen 2-amino-3-methylimidazo[4,5-f] quinoline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Metabolic activation of environmental carcinogens and mutagens by human liver microsomes. Role of cytochrome P-450 homologous to a 3-methylcholanthrene-inducible isozyme in rat liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Metabolic activation of pyrolysate arylamines by human liver microsomes; possible involvement of a P-488-H type cytochrome P-450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Comparative metabolism of benzo[a]pyrene and drugs in human liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Effect of smoking on caffeine clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

30 May 2018

Metabolic processing of 2-acetylaminofluorene by microsomes and six highly purified cytochrome P-450 forms from rabbit liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

29 November 2018

Decreased Concentration of Phenacetin in Plasma of Cigarette Smokers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=298137

29 November 2018

Variability in caffeine metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The caffeine CO2 breath test: dose response and route of N-demethylation in smokers and nonsmokers

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biotransformation of caffeine, paraxanthine, theophylline, and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome(s) P-450 in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biotransformation of caffeine by microsomes from human liver. Kinetics and inhibition studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A urinary metabolite ratio that reflects systemic caffeine clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demethylation studies. VI. Inhibition of hepatic microsomal oxygenation by .beta.-(2,4-dichloro-6-phenylphenoxy)ethylamine and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cigarette smoking on phenacetin metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of caffeine metabolism in the rat by 3-methylcholanthrene

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydratase from a single preparation of rat liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the mechanism of activation of microsomal benzo[a]pyrene hydroxylation by flavonoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[2-14C]caffeine metabolism in control and 3-methylcholanthrene induced rat liver microsomes by high pressure liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production and application of antibodies to rat liver cytochrome P-450

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the cytochrome P-448 dependent liver enzyme system by a caffeine breath test

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine disposition after oral doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/2813353

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.86.20.7696

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1989PNAS...86.7696B

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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