Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome (Q24531946)

1

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Channing Der

8

object named as

Channing J Der

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Leslie B Gordon

7

object named as

Leslie B Gordon

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author name string

Michael R Erdos

2

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James P Madigan

3

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James J Fiordalisi

4

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Renee Varga

5

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Karen N Conneely

6

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Adrienne D Cox

Proceedings of the National Academy of Sciences of the United States of America

9

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language of work or name

English

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publication date

6 September 2005

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published in

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volume

102

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issue

36

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page(s)

12879-84

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cites work

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

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Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

24 March 2017

1 reference

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Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy

24 March 2017

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Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

24 March 2017

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Nuclear lamins: building blocks of nuclear architecture

24 March 2017

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Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

24 March 2017

1 reference

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Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy

24 March 2017

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Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia

24 March 2017

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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

24 March 2017

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Hutchinson-Guilford progeria syndrome

24 March 2017

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Congenital Absence of Hair and Mammary Glands with Atrophic Condition of the Skin and its Appendages, in a Boy whose Mother had been almost wholly Bald from Alopecia Areata from the age of Six.

24 March 2017

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The nuclear lamina comes of age.

27 September 2017

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27 September 2017

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Farnesyltransferase inhibitors as anticancer agents: critical crossroads.

27 September 2017

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The laminopathies: nuclear structure meets disease

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Sch-66336 (sarasar) and other benzocycloheptapyridyl farnesyl protein transferase inhibitors: discovery, biology and clinical observations

27 September 2017

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Lamin a truncation in Hutchinson-Gilford progeria.

27 September 2017

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Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

27 September 2017

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Farnesyltransferase inhibitors: promises and realities

27 September 2017

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Farnesyl protein transferase inhibition: a novel approach to anti-tumor therapy. the discovery and development of SCH 66336.

27 September 2017

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

27 September 2017

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Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

27 September 2017

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Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

27 September 2017

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Membrane-associated lamins in Xenopus egg extracts: identification of two vesicle populations

27 September 2017

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Cardiovascular abnormalities in progeria. Case report and review of the literature.

27 September 2017

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The Hutchinson-Gilford progeria syndrome. Report of 4 cases and review of the literature

27 September 2017

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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

27 September 2017

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Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study.

27 September 2017

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Isoprenylation is required for the processing of the lamin A precursor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1200293

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

30 May 2018

1 reference

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Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

29 November 2018

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The role of isoprenylation in membrane attachment of nuclear lamins. A single point mutation prevents proteolytic cleavage of the lamin A precursor and confers membrane binding properties

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1200293

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16129833

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16129833

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Edible vaccines: not quite ready for prime time

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0506001102

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1073/PNAS.0506001102

1 reference

ADS bibcode

2005PNAS..10212879C

0 references

1 reference

1 reference

PubMed publication ID

16129833

1 reference