Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism (Q24534965)

22 June 2017

Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism (English)

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22 June 2017

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1 reference

Trevor P Baglin

1

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22 June 2017

Robin W Carrell

2

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22 June 2017

Frank C Church

3

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22 June 2017

Charles T Esmon

4

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22 June 2017

James A Huntington

5

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22 June 2017

language of work or name

English

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publication date

8 August 2002

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Proceedings of the National Academy of Sciences of the United States of America

22 June 2017

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22 June 2017

99

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22 June 2017

17

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22 June 2017

11079-11084

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Structure of a serpin-protease complex shows inhibition by deformation

22 June 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

The anticoagulant activation of antithrombin by heparin

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

The structure of a Michaelis serpin-protease complex

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Biological implications of a 3 A structure of dimeric antithrombin

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Raster3D Version 2.0. A program for photorealistic molecular graphics

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

An approach to multi-copy search in molecular replacement

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

24 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

24 March 2017

https://api.crossref.org/works/10.1073/PNAS.162232399

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

On the size of the active site in proteases. I. Papain

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Interaction of heparin cofactor II with neutrophil elastase and cathepsin G

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Miscellaneous algorithms for density modification

24 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Polymerization of plasminogen activator inhibitor-1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Formation of the antithrombin heterodimer in vivo and the onset of thrombosis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Comparison of heparin- and dermatan sulfate-mediated catalysis of thrombin inactivation by heparin cofactor II.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

The role of Arg46 and Arg47 of antithrombin in heparin binding.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

A player of many parts: the spotlight falls on thrombin's structure.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

On the activation of human leuserpin-2, a thrombin inhibitor, by glycosaminoglycans.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

The interaction of thrombin with fibrinogen. A structural basis for its specificity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Role of the proposed serpin-enzyme complex receptor recognition site in binding and internalization of thrombin-heparin cofactor II complexes by hepatocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Cellular internalization and degradation of antithrombin III-thrombin, heparin cofactor II-thrombin, and alpha 1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Role of arginine 132 and lysine 133 in heparin binding to and activation of antithrombin

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Mutagenesis of thrombin selectively modulates inhibition by serpins heparin cofactor II and antithrombin III. Interaction with the anion-binding exosite determines heparin cofactor II specificity

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Leukocyte chemoattractant peptides from the serpin heparin cofactor II.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

The N-terminal acidic domain of heparin cofactor II mediates the inhibition of alpha-thrombin in the presence of glycosaminoglycans

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Phylogenetic analyses of amino acid variation in the serpin proteins

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162232399

Vertebrate serpins: construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162232399

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162232399

Importance of lysine 125 for heparin binding and activation of antithrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162232399

Conformational changes in thrombin when complexed by serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162232399

Thrombin inhibition by HCII in the presence of elastase-cleaved HCII and thrombin–HCII complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162232399

The serpins: nature's molecular mousetraps

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123213

Role of thrombin anion-binding exosite-I in the formation of thrombin-serpin complexes

29 November 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162232399

Role of arginine 129 in heparin binding and activation of antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162232399

Formation of a noncovalent serpin-proteinase complex involves no conformational change in the serpin. Use of 1H-15N HSQC NMR as a sensitive nonperturbing monitor of conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162232399

Inactivation of thrombin by antithrombin is accompanied by inactivation of regulatory exosite I

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162232399

Heparin cofactor II-proteinase reaction products exhibit neutrophil chemoattractant activity

21 January 2018

1 reference

12 December 2020

Reactive site peptide structural similarity between heparin cofactor II and antithrombin III

1 reference

12 December 2020

Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101

1 reference

12 December 2020

Role of thrombin exosites in inhibition by heparin cofactor II

1 reference

12 December 2020

Characteristics of the chemotactic activity of heparin cofactor II proteolysis products

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.162232399

1 reference

22 June 2017

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1 reference