The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1 (Q24538981)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0071121

alpha9-beta1 integrin-VEGF-C complex

1 reference

Gene Ontology release 2020-05-02

Nicholas E Vlahakis

1

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Bradford A Young

series ordinal

2

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Amha Atakilit

series ordinal

3

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Dean Sheppard

series ordinal

4

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language of work or name

English

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publication date

11 February 2005

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published in

Journal of Biological Chemistry

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volume

280

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page(s)

4544-52

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issue

6

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cites work

Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D

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The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner

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Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

24 March 2017

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Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema

24 March 2017

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Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

24 March 2017

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Proteolytic processing regulates receptor specificity and activity of VEGF-C.

24 March 2017

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Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle

24 March 2017

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Multiple integrins mediate cell attachment to cytotactin/tenascin

24 March 2017

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24 March 2017

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Integrins: bidirectional, allosteric signaling machines

24 March 2017

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Integrins: versatility, modulation, and signaling in cell adhesion

24 March 2017

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Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

24 March 2017

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VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses

24 March 2017

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Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121)

24 March 2017

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Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

24 March 2017

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VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

24 March 2017

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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

24 March 2017

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VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane

24 March 2017

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Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor

24 March 2017

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The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin

24 March 2017

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Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2

24 March 2017

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The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin

24 March 2017

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The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1

24 March 2017

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Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C

24 March 2017

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Vascular-specific growth factors and blood vessel formation

24 March 2017

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Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

7 April 2017

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Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1).

7 April 2017

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27 September 2017

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Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells

27 September 2017

1 reference

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Tiny dancers: the integrin-growth factor nexus in angiogenic signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368959

Vascular growth factors and lymphangiogenesis

27 September 2017

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Molecular mechanisms of lymphangiogenesis in health and disease

27 September 2017

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Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma

27 September 2017

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Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis.

27 September 2017

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Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368959

Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368959

RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368959

Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1368959

c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro.

27 September 2017

1 reference

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Differential regulation of airway epithelial integrins by growth factors

27 September 2017

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Specific interaction of angiostatin with integrin alpha(v)beta(3) in endothelial cells

27 September 2017

1 reference

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Expression of vascular endothelial growth factor receptors 1, 2, and 3 in quiescent endothelia.

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412816200

Integrin regulation of growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412816200

Integrin activation is required for VEGF and FGF receptor protein presence on human microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412816200

Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412816200

Therapeutic lymphangiogenesis with human recombinant VEGF-C.

21 January 2018

1 reference

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A mechanism for modulation of cellular responses to VEGF: activation of the integrins

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15590642