Small molecule modulation of Smoothened activity (Q24540343)

2

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Keith E Young

3

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Tapan Maiti

4

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Philip A Beachy

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

29 October 2002

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published in

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volume

99

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issue

22

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page(s)

14071-6

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cites work

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

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Patched acts catalytically to suppress the activity of Smoothened

24 March 2017

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Sonic hedgehog induces the segregation of patched and smoothened in endosomes

24 March 2017

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Hedgehog signaling in animal development: paradigms and principles

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Transmembrane molecular pump activity of Niemann-Pick C1 protein

24 March 2017

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

24 March 2017

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Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

24 March 2017

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Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

24 March 2017

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An LDL-receptor-related protein mediates Wnt signalling in mice

24 March 2017

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

24 March 2017

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Altered neural cell fates and medulloblastoma in mouse patched mutants

24 March 2017

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arrow encodes an LDL-receptor-related protein essential for Wingless signalling

24 March 2017

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A new member of the frizzled family from Drosophila functions as a Wingless receptor

7 April 2017

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G protein-coupled receptor allosterism and complexing

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27 September 2017

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The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins.

27 September 2017

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Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression

27 September 2017

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The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

27 September 2017

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Biochemical evidence that patched is the Hedgehog receptor

27 September 2017

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The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

27 September 2017

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A frequent activated smoothened mutation in sporadic basal cell carcinomas

27 September 2017

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Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor

30 May 2018

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smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

30 May 2018

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A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

30 May 2018

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Hedgehog and patched in neural development and disease

30 May 2018

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The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.182542899

Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.

21 January 2018

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Teratogen-mediated inhibition of target tissue response to Shh signaling.

21 January 2018

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Medulloblastoma growth inhibition by hedgehog pathway blockade

21 January 2018

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Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.

21 January 2018

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The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137838

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12391318

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : I. Zygotic loci on the second chromosome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12391318

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.182542899

1 reference

2118215

ADS bibcode

2002PNAS...9914071C

0 references

2118215

1 reference

1 reference

1 reference