Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent (Q24545984)

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21 January 2020

title

Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent (English)

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21 January 2020

7

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21 January 2020

Jan Cools

9

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21 January 2020

author name string

Elizabeth H Stover

1

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21 January 2020

Jing Chen

2

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21 January 2020

Cedric Folens

3

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21 January 2020

Benjamin H Lee

4

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21 January 2020

Nicole Mentens

5

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21 January 2020

Peter Marynen

6

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21 January 2020

D Gary Gilliland

8

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21 January 2020

language of work or name

English

0 references

publication date

11 May 2006

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Proceedings of the National Academy of Sciences of the United States of America

21 January 2020

number of pages

6

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based on heuristic

inferred from page(s)

published in

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21 January 2020

volume

103

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21 January 2020

issue

21

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page(s)

8078-8083

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Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase

21 January 2020

cites work

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Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome

24 March 2017

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Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

24 March 2017

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The structural basis for autoinhibition of FLT3 by the juxtamembrane domain

24 March 2017

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A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

24 March 2017

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Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

24 March 2017

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CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy

24 March 2017

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ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain

24 March 2017

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Targeting mutated protein tyrosine kinases and their signaling pathways in hematologic malignancies.

24 March 2017

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Juxtamembrane autoinhibition in receptor tyrosine kinases.

27 September 2017

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An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice

27 September 2017

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PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease.

27 September 2017

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Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase

27 September 2017

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Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

27 September 2017

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PDGFRA activating mutations in gastrointestinal stromal tumors.

27 September 2017

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Definition of an inhibitory juxtamembrane WW-like domain in the platelet-derived growth factor beta receptor

27 September 2017

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The roles of FLT3 in hematopoiesis and leukemia

27 September 2017

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The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways

27 September 2017

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A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family.

27 September 2017

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The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.

30 May 2018

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Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness

21 January 2018

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Clinical and molecular features of FIP1L1-PDFGRA (+) chronic eosinophilic leukemias.

21 January 2018

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Molecular characterization of the idiopathic hypereosinophilic syndrome (HES) in 35 French patients with normal conventional cytogenetics.

21 January 2018

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The t(4;22)(q12;q11) in atypical chronic myeloid leukaemia fuses BCR to PDGFRA.

21 January 2018

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Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia

21 January 2018

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The hypereosinophilic syndrome: fluorescence in situ hybridization detects the del(4)(q12)-FIP1L1/PDGFRA but not genomic rearrangements of other tyrosine kinases.

21 January 2018

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Tyrosine kinases as targets for cancer therapy

28 November 2018

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21 January 2018

Identifiers

DOI

10.1073/PNAS.0601192103

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16690743%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

0 references

1 reference

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21 January 2020

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