Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis (Q24548215)

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Joon No Lee

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Michael S Brown

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Jin Ye

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

18 April 2006

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published in

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volume

103

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page(s)

6154-9

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issue

16

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cites work

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

24 March 2017

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Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.

24 March 2017

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Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

24 March 2017

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

24 March 2017

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

24 March 2017

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Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

24 March 2017

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Membrane topology of human insig-1, a protein regulator of lipid synthesis

24 March 2017

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

24 March 2017

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Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

24 March 2017

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Regulation of the mevalonate pathway

24 March 2017

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Protein sensors for membrane sterols

7 April 2017

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Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

7 April 2017

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Structural basis of FFAT motif-mediated ER targeting

27 September 2017

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Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change

27 September 2017

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VAMP-associated protein-A regulates partitioning of oxysterol-binding protein-related protein-9 between the endoplasmic reticulum and Golgi apparatus.

27 September 2017

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Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

27 September 2017

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Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells

27 September 2017

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The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase

27 September 2017

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Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

27 September 2017

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Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.

27 September 2017

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30 May 2018

19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S0021-9258(19)84879-2

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0601923103

Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0601923103

Position and ionization state of Asp in the core of membrane-inserted alpha helices control both the equilibrium between transmembrane and nontransmembrane helix topography and transmembrane helix positioning.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0601923103

19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16606821

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1073/PNAS.0601923103

Identifiers

DOI

10.1073/PNAS.0601923103

1 reference

3763156

ADS bibcode

2006PNAS..103.6154G

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3763156

1 reference

1 reference

1 reference